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最近の研究成果

Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters

Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1

Cryo-electron microscopic analysis reveal a novel structural unit of chromatin, H3-H4 octasome

CohesinDB: A comprehensive database for decoding cohesin-related epigenomes, 3D genomes and transcriptomes in human cells

Structural basis for the nucleosome binding by “Guardian of the genome” p53

Elucidation of the structural basis for binding of acetyltransferase p300 to the nucleosome

Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation

Elucidation of the functional ligand of LAG-3, a potential therapeutic target of cancer immunotherapy

PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity

Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant

List of researchers

List of research groups

Research Division for Quantitative Life Sciences

Laboratory of Genome Structure and Function
Katsuhiko Shirahige
Laboratory of Membrane Proteins
Chikashi Toyoshima
Laboratory of Chromatin Structure and Function
Hitoshi Kurumizaka
Laboratory of Molecular Neurobiology
Yusuke Kishi
Laboratory of chromosome configuration
Camilla Björkegren

Research Division for Applied Life Sciences

Laboratory of Pathology and Development
Yuki Okada
Laboratory of Immunology and Infection Control
Reiko Shinkura
Laboratory of Molecular Immunology
Taku Okazaki
Laboratory of RNP Synthetic Biology and Biotechnology
Hirohide Saito
Laboratory of Immunology and Immunopathology
Shunsuke Chikuma
Laboratory of Epithelial-Mesenchymal Plasticity
Ruby Yun-Ju Huang
Laboratory of Nucleic Acid Nanotechnology
Yusuke Sakai
Laboratory of Rare Disease Research
Kosuke Izumi

Research Center for Biological Visualization

Laboratory of Genome Regeneration
Takehiko Kobayashi
Laboratory of Transcription Dynamics
Takashi Fukaya
Laboratory of DNA Topology and Genome Maintenance
Kristian Jeppsson
Laboratory of Functional Nuclear Imaging
Hiroshi Kimura
Laboratory of Epitranscriptomics
Tsutomu Suzuki

Research Center for Cellular Dynamics

Laboratory of Molecular and Genetic Information
Tetsu Akiyama
Laboratory of Cell Growth and Differentiation
Atsushi Miyajima
Laboratory of RNA Function
Yukihide Tomari
Laboratory of Behavioral Neuroscience
Teruhiro Okuyama
Laboratory of Computational Genomics
Ryuichiro Nakato
Laboratory of Neural Computation
Akihiro Funamizu
Laboratory of mRNA Translation
Hotaka Kobayashi
Laboratory of Oncoprotein Kinetics
Donald Cameron
Laboratory of Molecular Design
Björn Högberg

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