Pressrelease

2022-06-10 / Last updated : 2022-06-14 adiqb1 Laboratory of Chromatin Structure and Function

Elucidation of the structural basis for binding of acetyltransferase p300 to the nucleosome

Suguru Hatazawa
Yoshimasa Takizawa
Hitoshi Kurumizaka
iScience
  • The cryo-EM structures of the p300 catalytic core complexed with the nucleosome have been determined.
  • The p300 catalytic core binds to the nucleosome in multiple binding modes, allowing p300 to acetylate various target sites within the nucleosomal histone tails.
  • The structures of p300-nucleosome complex provide insights into drug development for p300, as its defects are known for causing various diseases.

 

Pressrelease
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Journals

Journal: iScience

Title: Structural basis for binding diversity of acetyltransferase p300 to the nucleosome

Author: Suguru Hatazawa, Jiuyang Liu, Yoshimasa Takizawa, Mohamad Zandian, Lumi Negishi, Tatiana G. Kutateladze, and Hitoshi Kurumizaka


DOI: 10.1016/j.isci.2022.104563

URL：https://www.cell.com/iscience/fulltext/S2589-0042(22)00835-5

Contact

Hitoshi Kurumizaka

Professor, Institute for Quantitative Biosciences