Pressrelease

2022-09-06 / Last updated : 2022-09-06 adiqb1 Laboratory of Chromatin Structure and Function

Structural basis for the nucleosome binding by “Guardian of the genome” p53


Masahiro Nishimura
Yoshimasa Takizawa
Kayo Nozawa
Hitoshi Kurumizaka
  • Cryo-EM structures of “Guardian of the genome” p53 complexed with nucleosome have been determined.
  • The p53 binding induces the nucleosomal linker DNA release from the histone core.
  • The structures of the p53-nucleosome complex provide significant insight into drug development for tumorigenesis, as many cancer bear alterations of the DNA sequence recognition by p53.

 

Pressrelease
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Journals

Journal: PNAS Nexus

Title: Structural basis for the p53 binding to its nucleosomal target DNA sequence

Author: Masahiro Nishimura, Yoshimasa Takizawa, Kayo Nozawa, and Hitoshi Kurumizaka

DOI: 10.1093/pnasnexus/pgac177

URL：https://academic.oup.com/pnasnexus/advance-article-abstract/doi/10.1093/pnasnexus/pgac177/6691728

Contact

Hitoshi Kurumizaka

Professor, Institute for Quantitative Biosciences