We identified a senescence factor that alters rDNA stability and induces cellular senescence in the budding yeast. In budding yeast, rDNA stability can impact cellular senescence. Spt4 is a transcription elongation factor that activates transcription of non-coding RNA in the rDNA, which induces rDNA instability and accelerates cellular senescence. The function of Spt4 becomes more important as cells age. We think Spt4 restricts the lifespan through rDNA destabilization.
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Journals
Journal:
Cell Reports
Title: Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters
Author: Masaaki Yokoyama, Mariko Sasaki and Takehiko Kobayashi
DOI: 10.1016/j.celrep.2022.111944
URL:
https://doi.org/10.1016/j.celrep.2022.111944
Contact
Takehiko Kobayashi
Professor, Institute for Quantitative Biosciences
