- We have succeeded in eliciting PD-1 function by removing its functional restriction.
- PD-1-elicitation alleviated autoimmune symptoms in animal models of rheumatoid arthritis, multiple sclerosis, and Sjögren’s syndrome.
- Current findings are expected to open a new avenue for the development of new immuno-regulatory therapies.
Pressrelease
(Go to the IQB Japanese Website)
Journals
Journal: Nature Immunology
Title: PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity
Author: Daisuke Sugiura, Il-mi Okazaki, Takeo K Maeda, Takumi Maruhashi, Kenji Shimizu, Rieko Arakaki, Tatsuya Takemoto, Naozumi Ishimaru, and Taku Okazaki
DOI: 10.1038/s41590-021-01125-7
URL：
https://www.nature.com/articles/s41590-021-01125-7
Contact
Taku Okazaki
Professor, Institute for Quantitative Biosciences
