Pressrelease

2022-11-08 / Last updated : 2022-11-10 adiqb1 Laboratory of Chromatin Structure and Function

Cryo-electron microscopic analysis reveal a novel structural unit of chromatin, H3-H4 octasome


Kayo Nozawa
Yoshimasa Takizawa
Hitoshi Kurumizaka
  • Cryo-EM structures of a novel nucleosome, the H3-H4 octasome, composed of four H3-H4 dimers without H2A-H2B have been determined.
  • In vivo crosslinking experiments supported the existence of the H3-H4 octasome in yeast cells.
  • The discovery of the unique structural characteristics of the H3-H4 octasome will have major impacts on topics ranging from chromatin structure and dynamics to epigenome regulation in eukaryotes.

 

 

Pressrelease
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Journals

Journal: The Proceedings of the National Academy of Sciences

Title: Cryo-electron microscopy structure of the H3-H4 ectosome—a nucleosome-like particle without histones H2A and H2B

Author: Kayo Nozawa, Yoshimasa Takizawa, Leonidas Pierrakeas, Chizuru Sogawa-Fujiwara, Kazumi Saikusa, Satoko Akashi, Ed Luk* and Hitoshi Kurumizaka*

DOI:10.1073/pnas.2206542119

URL：https://www.pnas.org/doi/10.1073/pnas.2206542119

Contact

Hitoshi Kurumizaka

Professor, Institute for Quantitative Biosciences