Pressrelease

2021-12-21 / Last updated : 2021-12-21 adiqb1 Laboratory of Chromatin Structure and Function

Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant

Seiya Hirai
Hitoshi Kurumizaka
Nucleic Acids Research

・The cryo-EM structure of the nucleosome containing the histone variant H3mm18 was determined.

・The H3mm18 nucleosome exhibits unique structure and stability.

・Ectopic expression of H3mm18 alters the gene expression profile and inhibits muscle differentiation.

 

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Journals

Journal: Nucleic Acids Research

Title: Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant

Author: Seiya Hirai, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Yoshimasa Takizawa, Tetsuro Komatsu, Taro Tachibana, Yutaro Fukushima, Yasuko Takeda, Lumi Negishi, Tomoya Kujirai, Masako Koyama, Yasuyuki Ohkawa, and Hitoshi Kurumizaka

DOI: 10.1093/nar/gkab1137

URL：https://doi.org/10.1093/nar/gkab1137

Contact

Hitoshi Kurumizaka

Professor, Institute for Quantitative Biosciences