Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant
Nucleic Acids Research
・The cryo-EM structure of the nucleosome containing the histone variant H3mm18 was determined.
・The H3mm18 nucleosome exhibits unique structure and stability.
・Ectopic expression of H3mm18 alters the gene expression profile and inhibits muscle differentiation.
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Journal: Nucleic Acids Research
Title: Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant
Author: Seiya Hirai, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Yoshimasa Takizawa, Tetsuro Komatsu, Taro Tachibana, Yutaro Fukushima, Yasuko Takeda, Lumi Negishi, Tomoya Kujirai, Masako Koyama, Yasuyuki Ohkawa, and Hitoshi Kurumizaka
Professor, Institute for Quantitative Biosciences