- Cryo-EM structures of the RNAPII-chromatosome complexes were determined. These structures reveal that H1 suppresses transcription elongation by RNAPII, unraveling the mechanisms by which H1 affects RNA polymerase II during transcription through nucleosomes.
- The structures of RNAPII-chromatosome complexes provide important insights into oncogenic mechanisms, as their defects are known to be involved in various cancers.
Pressrelease
(Go to the IQB Japanese Website)
Journals
Journal: Nature Communications
Title: Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Author: Rina Hirano, Haruhiko Ehara, Tomoya Kujirai, Tamami Uejima, Yoshimasa Takizawa, Shun-ichi Sekine, Hitoshi Kurumizaka.
DOI: 10.1038/s41467-022-35003-z
URL：
https://doi.org/10.1038/s41467-022-35003-z
Contact
Hitoshi Kurumizaka
Professor, Institute for Quantitative Biosciences
