Pressrelease

2023-05-16 / Last updated : 2023-08-18 adiqb Laboratory of Chromatin Structure and Function

Elucidating the Mechanism of Distinct DNA Repair Pathways Triggered by Different Damage Locations within the Genome: How DNA “Folding” Determines the Repair Strategy


Ken Osumi
Hitoshi Kurumizaka
  • Cryo-electron microscopy was used to reveal how the DNA reading device, RNA polymerase II, detects damage within folded DNA (nucleosomes) inside cells.
  • The research team proposed a mechanism in which differences in DNA damage location cause changes in nucleosome orientation relative to RNA polymerase II, determining downstream repair pathways.
  • Understanding how DNA damage is directed to different downstream repair pathways could potentially contribute to the prevention of cancer development in cells.

 

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Journals

Journal: Journal of Molecular Biology

Title: Structural basis of damaged nucleotide recognition by transcribing RNA polymerase II in the nucleosome

Author: Ken Osumi, Tomoya Kujirai, Haruhiko Ehara, Mitsuo Ogasawara, Chiaki Kinoshita, Mika Saotome, Wataru Kagawa, Shun-ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka

DOI: 10.1016/j.jmb.2023.168130

URL: https://doi.org/10.1016/j.jmb.2023.168130

Contact

Hitoshi Kurumizaka

Professor, Institute for Quantitative Biosciences