Journals
Journal: Molecular CellTitle: Functional coordination between transcription factor clustering and gene activity
Author: Koji Kawasaki, Takashi Fukaya＊
DOI: 10.1016/j.molcel.2023.04.018
URL: https://doi.org/10.1016/j.molcel.2023.04.018
- Transcriptional bursting is regulated by dynamic transcription factor (TF) clustering at enhancers
- Intrinsically disordered regions (IDRs) facilitate TF clustering and subsequent burst induction
- Positive feedback regulation of TF clustering by active transcription
- Formation of a “shared” TF cluster mediates co-activation of distant genes
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Title: Functional coordination between transcription factor clustering and gene activity
Author: Koji Kawasaki, Takashi Fukaya＊
DOI: 10.1016/j.molcel.2023.04.018
URL: https://doi.org/10.1016/j.molcel.2023.04.018