Pressrelease

Unveiling the roles of non-coding enhancer transcription in living Drosophila embryos


Kota Hamamoto
Yusuke Umemura
Shiho Makino
Takashi Fukaya
  • We develop a novel live-imaging system for simultaneous visualization of gene transcription along with intergenic non-coding transcription at the single-cell resolution in Drosophila.
  • Live-imaging analysis reveals that non-coding enhancer transcription leads to suppression of linked gene.
  • Our findings provide concrete molecular explanation for the mechanism of transcriptional regulation via non-coding enhancer transcription during animal development.

 

 

Pressrelease
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Journals

Journal: Nature Communications

Title: Dynamic interplay between non-coding enhancer transcription and gene activity in development

Author: Kota Hamamoto, Yusuke Umemura, Shiho Makino, Takashi Fukaya*

DOI: 10.1038/s41467-023-36485-1

URL: https://doi.org/10.1038/s41467-023-36485-1

Contact

Takashi Fukaya

Associate Professor, Institute for Quantitative Biosciences