- We develop a novel live-imaging system for simultaneous visualization of gene transcription along with intergenic non-coding transcription at the single-cell resolution in Drosophila.
- Live-imaging analysis reveals that non-coding enhancer transcription leads to suppression of linked gene.
- Our findings provide concrete molecular explanation for the mechanism of transcriptional regulation via non-coding enhancer transcription during animal development.
Pressrelease
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Journals
Journal:
Nature Communications
Title: Dynamic interplay between non-coding enhancer transcription and gene activity in development
Author: Kota Hamamoto, Yusuke Umemura, Shiho Makino, Takashi Fukaya*
DOI: 10.1038/s41467-023-36485-1
URL:
https://doi.org/10.1038/s41467-023-36485-1
Contact
Takashi Fukaya
Associate Professor, Institute for Quantitative Biosciences