◆Neural encoding of reward prediction is unclear compared to the encoding of sensory inputs or action selection.
◆We found that the cerebral cortex of mice locally represents the sensory inputs and choices, while it globally represents the reward prediction.
◆Improper prediction of rewards or conditions may lead to visual, auditory and other hallucinations. We believe that this study contributes to understand the mechanism of mental disorders related to prediction.
Pressrelease
(Go to the IQB Japanese Website)
Featured image
Journals
Journal:
Nature Communications
Title: Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex
Author: Kotaro Ishizu, Shosuke Nishimoto, Yutaro Ueoka, Akihiro Funamizu*
DOI: 10.1038/s41467-024-48338-6
URL: https://www.nature.com/articles/s41467-024-48338-6
Contact
Institute for Quantitative Biosciences, The University of Tokyo
Akihiro Funamizu
Lecturer
