Pressrelease

2024-06-07 / Last updated : 2024-06-07 adiqb Laboratory of Cell Growth and Differentiation

Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use


National Center for Global Health and Medicine
The University of Tokyo
  • We have succeeded in the generation of human hepatobiliary organoids (hHBOs), which can reproduce the bile flow from hepatocyte into bile duct via bile canaliculi.
  • The hHBO could recapitulate pathological responses such as cholestasis and cytotoxicity to troglitazone like the human liver.
  • The hHBO would be a novel in vitro platform system for pharmaceutical research use.

 

Pressrelease
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Journals

Journal: Biomaterials

Title:Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use

Author:Luyao Wang, Yuta Koui, Kazuko Kanegae, Taketomo Kido, Miwa Tamura-Nakano, Shigeharu Yabe, Kenpei Tai, Yoshiko Nakajima, Hiroyuki Kusuhara, Yasuyuki Sakai, Atsushi Miyajima, Hitoshi Okochi, Minoru Tanaka*

DOI:　10.1016/j.biomaterials.2024.122621

URL:　https://doi.org/10.1016/j.biomaterials.2024.122621

Contact

Institute for Quantitative Biosciences, The University of Tokyo
Minoru Tanaka
Associate Professor