Pressrelease

2024-04-24 / Last updated : 2024-05-27 adiqb Laboratory of Chromatin Structure and Function

High-speed atomic force microscopy reveals dynamics of nucleosomes that lack histone tails

  • Mikihiro Shibata’s group (WPI-NanoLSI, Kanazawa Univ.), in collaboration with Hitoshi Kurumizaka’s group (IQB, The Univ. of Tokyo), succeeded in visualization of nucleosomes without histone tails using high-speed atomic force microscopy.
  • Nucleosomes lacking H2B or H3 tails displayed enhanced DNA unwrapping from the histone core.
  • Nucleosomes lacking H2B or H3 tails also showed a higher frequency of nucleosome sliding compared with wild-type nucleosomes.

 

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Journals

Journal: Nano Letters

Title: High-Speed Atomic Force Microscopy Reveals the Nucleosome Sliding and DNA Unwrapping/Wrapping Dynamics of Tail-less Nucleosomes

Author: Takumi Oishi, Suguru Hatazawa, Hitoshi Kurumizaka*

DOI:　10.1021/acs.nanolett.4c00801

URL:https://pubs.acs.org/doi/10.1021/acs.nanolett.4c00801

Contact

Institute for Quantitative Biosciences, The University of Tokyo
Hitoshi Kurumizaka
Professor