Brain function declines with aging, and we found that the dynamics of neuronal nuclei decline in the process.
We found that the nuclei of neurons in the visual cortex show less frequent nuclear infolding upon neural activity during brain aging, and they become stiffer.
Further studies could potentially contribute to the elucidation of the causes and treatment of age-related neurological diseases.
Pressrelease
(Go to the IQB Japanese Website)
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Journals
Journal:
Aging Cell
Title: Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex
Author:Tanita Frey, Tomonari Murakami, Koichiro Maki, Takumi Kawaue, Naoki Tani, Ayaka Sugai, Naotaka, Nakazawa, Kei-ichiro Ishiguro, Taiji Adachi, Mineko Kengaku, Kenichi Ohki, Yukiko Gotoh, and Yusuke Kishi*
DOI: 10.1111/acel.13925
URL:
https://onlinelibrary.wiley.com/doi/10.1111/acel.13925
Contact
Yusuke Kishi
Associate Professor, Institute for Quantitative Biosciences
