3D genome structure revealed by data-driven analysis -CustardPy, a new computational method for 3D genome analysis-
◆We have developed CustardPy, a novel computational method for the integrative analysis of large-scale genomic data.
◆Using CustardPy, we have elucidated some aspects of the complex 3D genome structure and its functions, including the discovery of a specific 3D structure strongly associated with gene expression regulation.
◆ The results of this research will help elucidate the mechanism of several diseases caused by disruption of the 3D genome structure, including cancer.
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Journal: Nature Communications
Title: Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors
Author:Ryuichiro Nakato*, Toyonori Sakata, Jiankang Wang, Luis Augusto Eijy Nagai, Yuya Nagaoka, Gina Miku Oba, Masashige Bando and Katsuhiko Shirahige*
Associate Professor, Institute for Quantitative Biosciences