- We found that when mice respond to the fear of other mice, neurons in the ventromedial prefrontal cortex (vmPFC) represents both the fear of others and the observer mouse’s own fear responses.
- Combined with automatic behavior analysis, we discovered that the vmPFC regulates escape behavior, and that vmPFC neurons simultaneously represent both self- and other-information.
- Empathy plays an important role in developing positive relationships in our daily lives. Understanding its neural basis can provide implications for autism spectrum disorders, in which individuals often struggle with empathizing.
Pressrelease
(Go to the IQB Japanese Website)
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Journals
Journal:
Nature Communications
Title: Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice
Author: Ziyan Huang, Myung Chung, Kentaro Tao, Akiyuki Watarai, Mu-Yun Wang, Hiroh Ito, Teruhiro Okuyama*
DOI: 10.1038/s41467-023-39081-5
URL:
https://doi.org/10.1038/s41467-023-39081-5
Contact
Teruhiro Okuyama
Associate Professor, Institute for Quantitative Biosciences