Pressrelease

How the brain works in empathy -Discovery of neurons that simultaneously represent self- and other-information-


Ziyan Huang
Myung Chung
Kentaro Tao
Akiyuki Watarai
Mu-Yun Wang
Hiroh Ito
Teruhiro Okuyama
  • We found that when mice respond to the fear of other mice, neurons in the ventromedial prefrontal cortex (vmPFC) represents both the fear of others and the observer mouse’s own fear responses.
  • Combined with automatic behavior analysis, we discovered that the vmPFC regulates escape behavior, and that vmPFC neurons simultaneously represent both self- and other-information.
  • Empathy plays an important role in developing positive relationships in our daily lives. Understanding its neural basis can provide implications for autism spectrum disorders, in which individuals often struggle with empathizing.

 

 

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Journals

Journal: Nature Communications

Title: Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice

Author: Ziyan Huang, Myung Chung, Kentaro Tao, Akiyuki Watarai, Mu-Yun Wang, Hiroh Ito, Teruhiro Okuyama*

DOI: 10.1038/s41467-023-39081-5

URL: https://doi.org/10.1038/s41467-023-39081-5

Contact

Teruhiro Okuyama

Associate Professor, Institute for Quantitative Biosciences