Regulation of transcriptional bursting by core promoter elements

Moe Yokoshi
Koji Kawasaki
Takashi Fukaya
Nucleic Acids Research

◆ We developed a live-imaging system that permits systematic visualization of the roles of individual core promoter elements in living Drosophila embryo.

◆ Quantitative image analysis revealed that each core promoter elements differentially regulates the amplitude and the frequency of transcriptional bursting.

◆ Engineering of the core promoter region of endogenous fushi tarazu gene revealed that both TATA and DPE are essential for its correct expression and function during embryogenesis.


(Go to the IQB Japanese Website)


Journal: Nucleic Acids Research

Title: Dynamic modulation of enhancer responsiveness by core promoter elements in living Drosophila embryos

Author: Moe Yokoshi, Koji Kawasaki, Manuel Cambón, Takashi Fukaya

DOI: 10.1093/nar/gkab1177



Takashi Fukaya

Associate professor, Institute for Quantitative Biosciences