◆ We developed a live-imaging system that permits systematic visualization of the roles of individual core promoter elements in living Drosophila embryo.
◆ Quantitative image analysis revealed that each core promoter elements differentially regulates the amplitude and the frequency of transcriptional bursting.
◆ Engineering of the core promoter region of endogenous fushi tarazu gene revealed that both TATA and DPE are essential for its correct expression and function during embryogenesis.
Pressrelease
(Go to the IQB Japanese Website)
Journals
Journal: Nucleic Acids Research
Title: Dynamic modulation of enhancer responsiveness by core promoter elements in living
Drosophila embryos
Author: Moe Yokoshi, Koji Kawasaki, Manuel Cambón, Takashi Fukaya
DOI: 10.1093/nar/gkab1177
URL：
https://doi.org/10.1093/nar/gkab1177
Contact
Takashi Fukaya
Associate professor, Institute for Quantitative Biosciences
