Sequence homogeneity is highly controlled in human ribosomal RNA gene cluster
- The human rDNA is quite regular, suggesting that homogenization through gene conversion frequently occurs between copies.
- All of the intergenic non-coding regions (IGS) are heavily methylated, whereas about half of the coding regions are clearly unmethylated, and the active copy number seems constant.
- The rDNA in cells from progeroid syndrome patients who have reduced DNA repair activity have more unstable copies as compared with control normal cells.
(Go to the IQB Japanese Website)
Journal: Genome Research
Title: The human ribosomal RNA gene is composed of highly homogenized tandem clusters
Author: Yutaro Hori, Akira Shimamoto and Takehiko Kobayashi
Laboratory of Genome Regeneration