2021-08-26
/ Last updated : 2021-08-26
adiqb
Laboratory of Molecular Immunology
PD-1 preferentially inhibits the activation of low affinity T cells
Kenji Shimizu
Daisuke Sugiura
Il-mi Okazaki
Takumi Maruhashi
Tatsuya Takemoto
Taku Okazaki
Proceedings of the National Academy of Sciences of the United States of America
- PD-1 does not uniformly suppress T cells with diverse response characteristics but preferentially suppresses T cells with low affinity to antigen.
- Low affinity tumor-specific T cells preferentially expand in the absence of PD-1-mediated co-inhibitory signal.
- Precise and deeper understandings of the functional characteristics of PD-1 will support the development of effective and safe immunotherapies.
Pressrelease
(Go to the IQB Japanese Website)
Journals
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Title: PD-1 preferentially inhibits the activation of low affinity T cells
Author: Kenji Shimizu, Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi, Tatsuya Takemoto, and Taku Okazaki
DOI:
10.1073/pnas.2107141118
Contact
Laboratory of Molecular Immunology
Professor
Taku Okazaki
