Pressrelease

2021-08-06 / Last updated : 2021-08-13 adiqb Laboratory of Chromatin Structure and Function

Elucidation of the structural basis for DNA compaction in the human parasite Giardia lamblia

Shoko Sato
Yoshimasa Takizawa
Hitoshi Kurumizaka
Nucleic Acids Research
  • We succeeded for the first time in determining the nucleosome structure of the human parasite Giardia lamblia (G. lamblia) using cryo-electron microscopy analysis.
  • We found that the DNA ends of the G. lamblia nucleosome are flexible and that the acidic patch on the G. lamblia nucleosome is substantially different from those of higher eukaryotes.
  • Giardia lamblia is one of the most infectious pathogenic parasites in the world, and this study is expected to provide important insights for structure-informed drug development.

 

Pressrelease
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Journals

Journal: Nucleic Acids Research

Title: Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones

Author: Shoko Sato*, Yoshimasa Takizawa*, Fumika Hoshikawa, Mariko Dacher, Hiroki Tanaka, Hiroaki Tachiwana, Tomoya Kujirai, Yukari Iikura, Cheng-Han Ho, Naruhiko Adachi, Indu Patwal, Andrew Flaus, and Hitoshi Kurumizaka*

DOI: 10.1093/nar/gkab644

Contact

Laboratory of Chromatin Structure and Function

Professor
Hitoshi Kurumizaka