◆ RAD51 plays a central role in the double-strand break (DSB) repair induced by mutagens such as radiation, and the mechanism by which RAD51 initiates DSB repair on chromatin has been elucidated.
◆ The N-terminal domain of RAD51 is essential for the nucleosome binding and many mutations in this domain have been reported in cancer patients.
◆ This research will contribute to a therapeutic approach targeting the function of the RAD51 N-terminal domain.
Pressrelease
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Journals
Journal:
Nature
Title: Cryo-electron microscopy structures of human RAD51-nucleosome complexes reveal how RAD51 assembles on DSB site in chromatin
Author: Takuro Shioi, Suguru Hatazawa, Yoshimasa Takizawa, Hitoshi Kurumizaka＊
DOI: 10.1038/s41586-024-07196-4
URL: https://doi.org/10.1038/s41586-024-07196-4
Contact
Institute for Quantitative Biosciences, The University of Tokyo
Hitoshi Kurumizaka
Professor, Institute for Quantitative Biosciences
