Pressrelease

2024-02-13 / Last updated : 2024-02-14 adiqb Laboratory of DNA Topology and Genome Maintenance

Discovery of a mechanism to deal with “kinks” in DNA strands –Smc5/6 complex is a molecular motor that recognizes positively supercoiled DNA–


Kristian EL Jeppsson
Takashi Sutani
Katsuhiko Shirahige

 

◆ We found that torsional stress in DNA strands downstream of the gene transcription machinery (RNA polymerase II) are recognized by the Smc5/6 complex, a DNA pump.
◆ We proposed a model in which DNA regions with accumulated torsional stress are organized into a loop-like structure in the cell nucleus.
◆ This work is expected to contribute to the understanding of the mechanism that cells have to prevent cancer development and aging (that is, genome maintenance mechanism).

 

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Journals

Journal: Molecular Cell

Title: Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils

Author:

Institute for Quantitative Biosciences, The University of Tokyo
・Kristian EL Jeppsson, Lecturer (At the time of the research; Research Fellow at Karolinska Institutet and Research Fellow of the University of Tokyo (JSPS Postdoctoral Fellowship for Foreign Researchers))
 ・Takashi Sutani, Associate Professor
 ・Katsuhiko Shirahige, Professor (Concurrent post; Karolinska Institute, Visiting Professor)

Karolinska Institutet
 ・Camilla Björkegren, Professor  (Concurrent post; The University of Tokyo, Visiting Professor)

Max Planck Institute
 ・Eugene Kim, Group Leader

DOI:　 10.1016/j.molcel.2024.01.005

URL:https://doi.org/10.1016/j.molcel.2024.01.005

Contact

Institute for Quantitative Biosciences, The University of Tokyo
    Kristian EL Jeppsson, Lecturer
    Takashi Sutani, Associate Professor
    Katsuhiko Shirahige, Professor