Ribosome stalling mediated by small RNAs in plants: its mechanisms and unexpected function

Hiro-oki Iwakawa
Yukihide Tomari
Cell Reports
  • We revealed the mechanisms and an unexpected function of ribosome stalling mediated by microRNAs.
  • We found that microRNA-mediated ribosome stalling enhances the production of secondary siRNAs that regulate the stress responses and plant development.
  • The knowledge obtained from this research could be exploited to develop novel techniques that allow efficient expression of transgenes by suppressing undesirable RNA silencing.


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Journal: Cell Reports
Title: Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants
Author: Hiro-oki Iwakawa*, Andy Y.W. Lam, Akira Mine, Tomoya Fujita, Kaori Kiyokawa, Manabu Yoshikawa, Atsushi Takeda, Shintaro Iwasaki, Yukihide Tomari.
DOI: 10.1016/j.celrep.2021.109300


Laboratory of RNA Function

Hiro-oki Iwakawa