研究分野の概略

Promoting international exchange through research collaborations

研究内容の紹介

Promoting international exchange through research collaborations

In my role as visiting professor at Institute for Quantitative Biosciences I have two major goals. The first is to continuously develop the UTokyo-KI link program which promotes internationalization through research and educational exchange. The second is to collaborate with other principal investigators at the institute to reveal the role of a newly discovered interplay between DNA structure and chromosome dynamics during development and cellular growth.

論文一覧

  1. Pradhan B1, Kanno T1, Umeda Igarashi M, Loke MS, Baaske MD, Wong JSK, Jeppsson K, Björkegren C*, Kim E*. The Smc5/6 complex is a DNA loop-extruding motor. Nature. 2023, 616 ; 843-848. doi: 10.1038/s41586-023-05963-3. 1Equal contribution. *Co-corresponding authors.
  2. Jeppsson K, Sakata T., Nakato R., Milanova S., Shirahige K., Björkegren C. 2022. Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks. Science Advances, doi:10.1126/sciadv.abn7063
  3. Kanno T., Berta D., Sjögren C. 2015. The Smc5/6 complex is an ATP-dependent intermolecular DNA linker. Cell Reports,doi: 10.1016/j.celrep.2015.07.048.
  4. Jeppsson K., Carlborg K., Nakato R., Berta D., Lilienthal I., Kanno T., Lindqvist A., Brink M., Dantuma N., Katou Y., Shirahige K., Sjögren C. 2014 The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement. PLoS Genet; doi: 10.1371/journal.pgen.1004680
  5. Jeppsson K., Kanno T., Shirahige K., and Sjögren C.2014. The maintenance of chromosome structure: positioning and function of SMC complexes. Invited review, Nat. Rev. Mol. Cell Biol. 15; 601-14
  6. Lilienthal I, Kanno T, Sjögren C. 2013. Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels. PLoS Genet.,9(11): e1003898. doi: 10.1371/journal.pgen.1003898.
  7. Carter Dewey S. and Sjögren C. The SMC complexes, DNA and chromosome topology –right or knot? 2012. Invited review. Crit. Rev. Biochem. Mol. Biol. 2012; 47;1-1
  8. Kegel A., Betts-Lindroos H., Kanno K., Jeppsson K., Ström L.,Katou Y., Itoh T., Shirahige S., Sjögren C. 2011. Chromosome length influences replication-induced topological stress. Nature, 471; 392-396.
  9. Ström L., Karlsson C., Betts Lindroos H., Wedahl S., Katou Y., Shirahige K., Sjögren C. 2007. Post-replicative formation of cohesion is required for repair and induced by a single DNA break. Science, 317; 242-245.
  10. Betts Lindroos H., Ström. L., Itoh T., Katou, Y., Shirahige K., and Sjögren C. 2006. Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol. Cell, 22; 755- 767.
カミラ　ビヨルケグレン　客員教授
Camilla Björkegren
Ph.D.