Pressrelease

2025-07-10 / Last updated : 2025-07-10 adiqb Laboratory of Molecular Neurobiology

Chromatin changes during the developmental stage “prepare” neurons for functional acquisition.

Pressrelease
(Go to the IQB Japanese Website)We have developed a simple method to label specific types of neurons that share the same “birthdate.”
We discovered that chromatin structure changes occurring during the four days following differentiation are critical for the functionality of mature neurons.
This research is expected to shed light on the characteristics of different neuron types and contribute to understanding the principles of brain construction and operation.

Journals

Journal: Development
Title:In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex
Author: Seishin Sakai, Yurie Maeda, Mai Saeki, Daijiro Konno, Keita Kawaji, Fumio Matsuzaki, Yutaka Suzuki, Yukiko Gotoh*, Yusuke Kishi*
DOI：10.1242/dev.204564
URL：https://journals.biologists.com/dev/article/152/13/dev204564/368413/In-vivo-transition-in-chromatin-accessibility

Contact

General Affairs Team, Institute for Quantitative Biosciences, The University of Tokyo