Key Points of Our Findings
◆ We discovered a mechanism that properly regulates the size of DNA loops on chromosomes during cell division. When this mechanism is disrupted, chromosomes fail to separate smoothly.
◆ We revealed that the size of DNA loops is determined by the interaction strength between two key factors: cohesin and Scc2.
◆ Our findings improve the understanding of cancer and genetic disorders that are linked to chromosome segregation errors.
Pressrelease
(Go to the IQB Japanese Website)
Journals
Journal: iScience
Title: Regulation of pericentromeric DNA loop size via Scc2-cohesin interaction（In Press, Journal Pre-proof）
Author: Sao Anh Nguyen, Toyonori Sakata, Katsuhiko Shirahige
*, Takashi Sutani
*
DOI：https://doi.org/10.1016/j.isci.2025.112322
URL：https://www.sciencedirect.com/science/article/pii/S2589004225005838?via%3Dihub
Contact
General Affairs Team, Institute for Quantitative Biosciences, The University of Tokyo
