日　時：2024年2月20日（火）16:00-17:30（JST）

開催方法： Zoom開催

講　師：Saadi Khochbin, Ph.D.
　　　　Head of Epigenetics and Cell signalling Laboratory, Institute for Advanced Biosciences, Grenoble, France

演　題：
Nucleosome-to-nucleoprotamine transition: a black box in biology and a source of major discoveries in epigenetics

要　旨：
Over the past 25 years, we have made a sustained effort to understand the molecular mechanisms guiding the genome-wide histone-to-protamine replacement, which takes place during the post-meiotic maturation of male germ cells. The extreme nature of the epigenetic regulations operating during this global re-organization of the male genome has allowed our team to make important discoveries with general conceptual impact in epigenetics. These
findings shed a new light on the different events affecting chromatin, including the establishment of histone acetylation/acylation, their reading and the histone acetylation-acylation functional interplay, as well as on the function of specific histone variants. This research trend is now leading us to the general concept of metabolism-driven epigenetic regulations and invites researchers to revisit some of the well-established dogmas in chromatin biology and epigenetics.

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主　催︓ERATO胡桃坂クロマチンアトラスプロジェクト
共　催︓東京大学定量生命科学研究所