定量生命科学研究所セミナー(5月19日)

日時: 2023年5月19日(金)15:00-16:30

開催方法: Zoom開催

講師: Kazuhiro Iwai, M.D., Ph.D.
    Professor
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University

演題: Linear ubiquitination: Unexpected regulation and involvement in immunological disorders

要旨:
Linear (M1-linked) ubiquitin chains, which are exclusively generated by the LUBAC
ubiquitin ligase complex, played crucial roles in inflammatory signaling by inducing NF-kB
activation and suppressing programmed cell death including apoptosis and necroptosis.
LUBAC is composed of three subunits and the HOIP subunit has the catalytic center for
linear ubiquitination. The HOIL-1L subunit also has the E3 ligase center, however, precise
function of HOIL-1L E3 has not been elucidated. We unexpectedly found that HOIL-1L E3
attenuates LUBAC function by conjugating mono-ubiquitin to all three LUBAC subunits.
Introduction of E3-defective HOIL-1L mutants augments NF-kB activation and suppresses
programmed cell death. We are now dissecting roles of linear ubiquitination in
immunological disorders and found that augmented LUBAC activity appears causative to
some human autoimmune diseases. Our current progress will be presented in this lecture.

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幹事:クロマチン構造機能研究分野
主催:東京⼤学定量⽣命科学研究所
共催:ERATO胡桃坂クロマチンアトラスプロジェクト
後援:公益財団法⼈ 応⽤微⽣物学・分⼦細胞⽣物学研究奨励会