日時: 令和４年８月１９日（金曜）15:00 –16:00
場所 ： 東京大学 弥生キャンパス
講師: 吉良 信一郎 博士
(Harvard Medical School, Department of Neurobiology)
Decision-making requires flexibility to rapidly switch one’s actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns that mediate this flexibility during virtual-navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. An optogenetics screen identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid sensorimotor switching by encoding a conjunction of a current and remembered visual cue. This conjunctive code predicts the mouse’s navigational choice from trial-to-trial. These neurons formed efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, but were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network.