日時: 令和 4 年 5 月 26 日（木） 13:00~14:30
開催方法: ZOOM による配信 ※ 要・事前登録
講師: Frederic Berger, Ph.D.
Senior Group Leader
Laboratory of Chromatin Architecture and Function
Gregor Mendel Institute of Molecular Plant Biology, Vienna, Austria
演題: A redefined vision of the architecture of chromatin in the genomes of eukaryotes
Nucleosomes are defining features of eukaryotes that package DNA into the small space of the nucleus. They thereby prevent access to DNA and are considered general repressors of transcription. Nucleosomes are composed of the core histones H3, H4, H2A, and H2B. Histone variants are functionally-defined isoforms of core histones, that have markedly diversified in plants and mammals. Chromatin was reported to organize in a continuous variation of landscapes relative to transcriptional activity. We investigated how
combinations of histone variants and their modifications combine to produce chromatin landscapes over transposons and genes. We report that chromatin organizes into a limited number of stereotypic chromatin landscapes that distinguish families of transposons and distinct groups of genes. Unexpectedly, H2A variants are strong determinants in the architecture of these landscapes. Our work revises our vision of chromatin organization and will lead to find rules required to engineer predictably chromatin organization in synthetic eukaryotic systems.