日　　時：2024年9月17日（火）　16:00-17:00

場　　所： 弥生講堂アネックス　エンゼル研究棟講義室

講　　師：Prof. Chenqi Xu
　　　　　Deputy Director
　　　　　Shanghai Institute of Biochemistry and Cell Biology,
　　　　　Chinese Academy of Sciences Director, Key Laboratory of Multi-Cell Systems

演　　題：Harnessing charge-mediated immunoreceptor signaling in T cell therapy

要　　旨：
T cell immunity is a major pillar of the immune system in fighting with invading pathogens and tumors. Triggering of T cell immunity is orchestrated by a panel of immunoreceptors, including the antigen receptor TCR, the costimulatory/coinhibitory receptors and the cytokine receptors. Most of the immunoreceptors contain a juxtamembrane Basic Residue Rich Sequence (BRS) that can form an electrostatic network with neighboring lipids, proteins, and ions. Using TCR as a system, we show the importance of the BRS signaling in regulating safety, sensitivity, and specificity of T cell immunity and how to tune BRS signaling to promote the efficacy of TCR-T cell therapy. Moreover, introducing the BRS into Chimeric Antigen Receptor (CAR) improves antigen sensitivity and long-term persistence of CAR-T cells. Thus, harnessing natural charge power within the cellular signaling network represents a new
direction to improve therapeutic efficacies of immune cell therapies.

Yan et al, Cancer Cell, 41:1276 (2023)
Wu et al, Cell, 182:855 (2020)
Li et al, Immunity, 53:456 (2020)
Meng et al, Nature, 564:130 (2018)
Yang et al, Nature, 531:651 (2016)
Shi et al, Nature, 493:111 (2013)

幹　事︓分子免疫学研究分野
主　催︓東京大学定量生命科学研究所