2008N
"Novel tubulin-polymerization inhibitor derived from thalidomide directly
induces apoptosis in human multiple myeloma cells: Possible anti-myeloma
mechanism of thalidomide."
T. Iguchi, T. Noguchi-Yachide, Y. Hashimoto, S. Nakazato, M. Sagawa, Y.
Ikeda and M. Kizaki
Int. J. Mol. Med., 2008, 21(1), 163-168. |
"Fusarieline A as an anti-angiogenic and antiproliferative agent: its basic biological characterization"
Haruka Fujimoto, Hiroshi Aoyama, Tomomi Noguchi-Yachide, Yuichi Hashimoto
and Hisayoshi Kobayashi
Chem. Pharm. Bull., 2008, 56(3), 298-304. |
"SAR-oriented discovery of peroxisome proliferator-activated receptor
pan agonist with a 4-adamantylphenyl group as a hydrophobic tail"
Jun-ichi Kasuga, Daisuke Yamasaki, Kiyoshi Ogura, Motomu Shimizu, Mayumi
Sato, Makoto Makishima, Takefumi Doi, Yuichi Hashimoto and Hiroyuki Miyachi
Bioorg. Med. Chem. Lett., 2008, 18(3), 1110-1115. |
"Improvement of the transactivation activity of
phenylpropanoic acid-type peroxisome proliferator-activated receptor pan
agonists: Effect of introduction of fluorine at the linker part."
Kasuga JI, Oyama T, Hirakawa Y, Makishima M,
Morikawa K, Hashimoto Y, Miyachi H
Bioorg Med Chem Lett. 2008 Jul 15. PMID: 18662876 |
"Progesterone receptor antagonists with a@3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton"
Nakagawa A, Uno S, Makishima M, Miyachi H,
Hashimoto Y
Bioorg Med Chem. 2008 Jul 15;16(14): 7046-54. |
"4-(Anilino)pyrrole-2-carboxamides: Novel
non-steroidal/non-anilide type androgen antagonists effective upon human
prostate tumor LNCaP cells with mutated nuclear androgen receptor."
Wakabayashi K, Imai K, Miyachi H, Hashimoto Y,
Tanatani A
Bioorg Med Chem. 2008 Jul 15;16(14):6799-812. |
"Structural Development Studies of Subtype-Selective
Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the
3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template."
Miyachi H, Hashimoto Y
PPAR Res. 2008;2008:689859.@PMID: 18566690 |
"Coordination of divalent metal cation to amide
group to form adduct ion in FAB mass spectrometry: implication of Zn2+ in
enzymatic hydrolysis of amide bond."
Kobayashi H, Morisaki N, Miyachi H, Hashimoto Y
Chem Pharm Bull (Tokyo). 2008 May;56(5):672-6 |
"Demonstration of direct binding of cIAP1
degradation-promoting bestatin analogs to BIR3 domain: Synthesis and
application of fluorescent bestatin ester analogs"
Sato S, Aoyama H, Miyachi H, Naito M, Hashimoto Y
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3354-8. |
"Co-existence of alpha-glucosidase-inhibitory and
liver X receptor-regulatory activities and their separation by structural
development."
Dodo
K, Aoyama A, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y.
Bioorg Med Chem. 2008 Apr 15;16(8):4272-85.
|
"Degradation-promoters of cellular inhibitor of
apoptosis protein 1 based on bestatin and actinonin."
Sato S, Tetsuhashi M, Sekine K, Miyachi H, Naito M,
Hashimoto Y, Aoyama H
Bioorg Med Chem. 2008 Apr 15;16(8):4685-98 |
"1alpha,25-Dihydroxyvitamin D(3)-26,23-lactam
analogues function as vitamin D receptor antagonists in human and rodent cells"
Ishizuka S, Kurihara N, Hiruma Y, Miura D, Namekawa
J, Tamura A, Kato-Nakamura Y, Nakano Y, Takenouchi K, Hashimoto Y, Nagasawa K,
Roodman GD
J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):269-77 |
"New tubulin polymerization inhibitor derived from
thalidomide: implications for anti-myeloma therapy"
Kizaki M, Hashimoto Y
Curr Med Chem. 2008;15(8):754-65. Review. |
"Thalidomide as a Multi-Template for
Development of Biologically Active Compounds."
Hashimoto
Y.
Arch. Pharm. Life Sci., 341(9): 536-547 (2008). Review.
|
"Gamma-carboline derivatives with anti-bovine viral
diarrhea virus (BVDV) activity."
Sako
K, Aoyama H, Sato S, Hashimoto Y, Baba M.
Bioorg Med Chem. 2008 Apr 1;16(7):3780-90.
|
"Thiourea-catalyzed Morita-Baylis-Hilman Reaction."
Sohtome Y, Takemura N, Takagi R, Hashimoto Y and Nagasawa K.
Tetrahedron, 64(40): 9423-9429 (2008).
|
"Peroxisome proliferators-activated receptor (PPAR)
agonists with 3,4-dihydro-2H- benzo[e][1,3]oxazine and
2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine skeletons: Effects of cyclization of
linker moiety on PPAR-agonistic activity."
Ohgane K, Kasuga J, Ohyama T, Hirakawa Y, Morikawa K, Makishima M, Hashimoto Y and Miyachi H.
Heterocycles, 75(9): 2187-2192 (2008).
|
"LXR antagonists with a 5-substituted
phenanthridin-6-one skeleton: Synthesis and LXR transrepression activities of
conformationally restricted carba-T0901317 analogs."
Aoyama A, Aoyama H, Dodo K, Makishima M, Hashimoto Y and Miyachi H.
Heterocycles, 76(1): 137-142 (2008).
|
"Development of bifunctional acyclic hydroxyl-guanidine
organocatalyst: Application to asymmetric nucleophilic epoxidation."
Shin B, Tanaka S, Kita T, Hashimoto Y and Nagasawa K.
Heterocycles, 76(1): 801-810 (2008).
|
"Antiproliferative and apoptosis-inducing activities of
alkyl gallate and gallamide derivatives related to (-)-epigallocatechin
gallate."
Dodo K, Minato T, Noguchi-Yachide T, Suganuma M and Hashimoto Y.
Bioorg. Med. Chem., 16(17): 7975-7982
(2008).
|
"Structure-based design and synthesis of fluorescent PPAR Ώ/Β co-agonist
and its application as a probe for fluorescent polarization assay of PPARΒ
ligands."
Araya Y, Kasuga J, Toyota K, Hirakawa Y, Oyama T, Makishima M, Morikawa
K, Hashimoto Y and Miyachi H
Chem. Pharm. Bull., 56(9): 1357-1359 (2008).
|
"X-Ray crystallographic identification of bisulfite-uracil
adduct as sodium 5,6-dihydrouracil 6-sulfonate."
Kaneda M, Hashimoto Y and Hayatsu H.
Nucleic Acids Symp. Ser., 52(1): 451-452
(2008).
|
"Structural development of benzhydrol-type 1'-acetoxychavicol
acetate (ACA) analogs as human leukemia cell-growth inhibitors based on
quantitative structure-activity relationship (QSAR) analysis."
Misawa T, Aoyama H, Furuyama T,Dodo K, Sagawa M, Miyachi H, Kizaki M and
Hashimoto Y.
Chem. Pharm. Bull., 56(10): 1490-1495
(2008).
|
"Determination of the critical amino acids involved in the peroxisome proliferator-activated
receptor (PPAR) Β selectivity of phenylpropanoic acid-derived agonists"
Kasuga J, Oyama T, Nakagome I, Makishima M, Hirono S, Morikawa K, Hashimoto
Y and Miyachi H
ChemMedChem., 3(11): 1662-1666 (2008).
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