2005年
"Tubulin-polymerization inhibitors derived from thalidomide"
S. Inatsuki, T. Noguchi, H. Miyachi, S. Oda, T. Iguchi, M. Kizaki, Y. Hashimoto, and H. Kobayashi
Bioorg. Med. Chem. Lett., 2005,
15, 321-325 |
"Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its
metabolites"
T. Noguchi, C. Shinji, H. Kobayashi, M. Makishima, H. Miyachi, and Y. Hashimoto
Biol. Pharm. Bull.,
2005,
28, 563-564 |
"Novel non-steroidal/non-anilide type androgen antagonists: discovery
of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen
receptor ligands"
Ken-ichi Wakabayashi, Hiroyuki Miyachi, Yuichi Hashimoto and Aya Tanatani
Bioorg. Med. Chem.,
2005,
13(8), 2837-2846 |
"Design and synthesis of subtype-selective cyclooxyganase (COX) inhibitors
derived from thalidomide"
Hiroko Sano, Tomomi Noguchi, Aya Tanatani, Yuichi Hashimoto and Hiroyuki Miyachi
Bioorg. Med. Chem.,
2005,
13(9), 3079-3091 |
"Helical Structure of N-Alkylated Poly(p-benzamide)s"
Tanatani, A.; Yokoyama, A.; Azumaya, I.; Takakura, Y.; Mitsui, C.; Shiro, M.; Uchiyama, M.; Muranaka, A.; Kobayashi, N.; Yokozawa, T.
J. Am. Chem. Soc.,
2005,
127, 8553-8561 |
"A new class of androgen receptor antagonists bearing carborane in
place of a steroidal skeleton"
S. Fujii, Y. Hashimoto, T. Suzuki, S. Ohta and Y. Endo
Bioorg. Med. Chem. Lett., 2005,
15, 227-230 |
"Cell Differentiation Inducers Derived from Thalidomide"
T. Noguchi, H. Miyachi, R. Katayama, M. Naito, and Y. Hashimoto
Bioorg. Med. Chem. Lett., 2005,
15, 3212-3215 |
"Potent Androgen Antagonists Based on Carborane as a Hydropobic Core
Structure"
S. Fujii, T. Goto, K. Ohta, Y. Hashimoto, T. Suzuki, S. Ohta and Y. Endo
J. Med. Chem., 2005,
48, 4654-4662 |
"Nuclear receptor antagonists designed based on the helix-folding
inhibition hypothesis"
Y. Hashimoto, H. Miyachi
Bioorg. Med. Chem., 2005,
13(17), 5080-5093 |
"Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities"
S. Hosoda, A. Tanatani, K. Wakabayashi, Y. Nakano, H. Miyachi, K. Nagasawa
and Y. Hashimoto
Bioorg. Med. Chem. Lett., 2005,
15, 4327-4331 |
"Design and synthesis of phthalimide-type histone deacetylase inhibitors"
C. Shinji, T. Nakamura, S. Maeda, M. Yoshida, Y. Hashimoto and H. Miyachi
Bioorg. Med. Chem. Lett., 2005,
15, 4427-4431 |
"Angiogenesis inhibitors derived from thalidomide"
T. Noguchi, H. Fujimoto, H. Sano, A. Miyajima, H. Miyachi and Y. Hashimoto
Bioorg. Med. Chem. Lett., 2005,
15(24), 5509-5513 |
"Guanidine-thiourea bifunctional organocatalyst for the asymmetric
Henry (nitroaldol) reaction"
Y. Sohtome, Y. Hashimoto and K. Nagasawa
Adv. Synth. Catal., 2005,
347, 1643-1648 |
"Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and
identification of their target protein"
J. Shimokawa, T. Ishiwata, K. Shirai, H. Koshino, A. Tanatani, T. Nakata, Y.Hashimoto and K. Nagasawa
Chem. Eur. J., 2005,
11, 6878-6888 |
"Analysis of patent applications relating to peroxisome proliferator-activated
receptor (PPAR) ligands in 2004"
H. Miyachi
Expert Opin. Ther. Patent., 2005,
15, 1521-1530 |
"Lissoclibadins 1-3, three new polysulfur alkaloids, from the ascidian
Lissoclinum cf. badium"
HW Liu, T. Fujiwara, T. Nishikawa, Y. Mishima, H. Nagai, T. Shida, K. Tachibana, H. Kobayashi, REP. Mangindaan and M. Namikoshi
Tetrahedron, 2005,
61(36), 8611-8615 |
"Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes"
HW. Liu, M. Namikoshi, K. Akano, H. Kobayashi, H. Nagai and XS. Yao
J. Asian Nat. Prod. Res., 2005,
7(4), 661-670 |
"サリドマイドとがん治療"
野口友美，橋本祐一
がん分子標的治療, 2005,
3, 16-23 |
"薬害の克服を目指した創薬化学
サリドマイドをマルチ創薬テンプレートとして活用したサリドマイドの構造展開と活性拡張"
宮地弘幸，橋本祐一
ファルマシア, 2005,
41, 33-37 |
"PPARを標的とした創薬"
影近弘之，宮地弘幸
日本臨床, 2005,
63, 549-555 |
"新たなる創薬手法によるサリドマイドの構造展開とがん治療"
橋本祐一
血液・腫瘍科, 2005,
51(1), 7-15 |
"レチノイド受容体"
橋本祐一
生物薬科学実験講座 Vol.7-1. 情報伝達物質[1] 受容体, 石橋貞彦・市川厚・堅田利明編集、廣川書店、 pp. 218-230、2005 |
"生体内分子と反応する医薬品"
橋本祐一
「スタンダード薬学シリーズ」 第3巻 化学系薬学．ターゲット分子の合成と生体分子・医薬品の化学 第15章 日本薬学会編、東京化学同人、
pp. 235-240、2005 |
"レチノイドとサリドマイドをリードとする生物応答調節剤の創製研究 ― 構造展開と活性拡張―"
「ケミカルバイオロジー・ケミカルゲノミクス」 半田宏編、シュプリンガー・フェアラーク東京、
pp. 135-146、2005 |
"立体化学のための分析技術： NMR による解析"
小林久芳、降旗一夫
ぶんせき、2005,
3, 118-124 |
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