2006年
"Design and synthesis of substitited phenylpropanoic acid derivatives
as human peroxisome proliferator activated receptor α/δ dual
agonists"
J. Kasuga, M. Makishima, Y. Hashimoto and H. Miyachi
Bioorg. Med. Chem. Lett. 2006, 16(3), 554-558 |
"Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derevatives: Dual agonists for human peroxisome
proliferator activated receptor α and δ"
J. Kasuga, Y. Hashimoto and H. Miyachi
Bioorg. Med. Chem. Lett. 2006, 16(4), 771-774 |
"Practical synthesis and evaluation of the biological activities of
1α,25-dihydroxyvitamin D3 antagonists, 1α,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition
hypothesis"
Y. Nakano, Y. Kato, K. Imai, E. Ochiai, J. Namekawa, S. Ishizuka, K. Takenouchi,
A. Tanatani, Y. Hashimoto and K. Nagasawa
J. Med. Chem. 2006, 49(8), 2398-2406 |
"Anti-angiogenic activity of basic-type, selective cyclooxygenase
(COX)-1 inhibitors "
H. Sano, T. Noguchi, A. Miyajima, Y. Hashimoto and H. Miyachi
Bioorg. Med. Chem. Lett. 2006, 16(11), 3068-3072 |
"Diphenylmethane skeleton as a multi-template for nuclear receptor
ligands: Preparation of FXR and PPAR ligands"
M. Kainuma, J. Kasuga, S. Hosoda, K. Wakabayashi, A. Tanatani, K. Nagasawa,
H. Miyachi, M. Makishima and Y. Hashimoto
Bioorg. Med. Chem. Lett. 2006, 16(12), 3213-3218 |
"Effects of immunomodulatory derivatives of thalidomide (IMiDs) and
their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis"
H. Fujimoto, T. Noguchi, H. Kobayashi, H. Miyachi and Y. Hashimoto
Chem. Pharm. Bull. 2006, 54(6), 855-860 |
"Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D
and androgen receptors: Dual activities and metabolic activation"
S. Hosoda, A. Tanatani, K. Wakabayashi, M. Makishima, K. Imai, H. Miyachi,
K. Nagasawa and Y. Hashimoto
Bioorg. Med. Chem. 2006, 14(16), 5489-5502 |
"Tubulin polymerization inhibitors with a fluorinated phthalimide
skeleton derived from thalidomide"
T. Yanagawa, T. Noguchi, H. Miyachi, H. Kobayashi and Y. Hashimoto
Bioorg. Med. Chem. Lett. 2006, 16(18), 4748-4751 |
"Mono- and dihydroxylated metabolites of thalidomide: synthesis and
TNF-α production-inhibitory activity"
T. Nakamura, T. Noguchi, H. Kobayashi, H. Miyachi and Y. Hashimoto
Chem. Pharm. Bull. 2006, 54(12), 1709-1714 |
"Design, synthesis, and evaluation of a novel series of α-substituted
phenylpropanoic acid derivatives as human peroxisome proliferator-activated
receptor (PPAR) α/δ dual agonists for the treatment of metabolic
syndrome"
J. Kasuga, D. Yamasaki, Y. Araya, A. Nakagawa, M. Makishima, T. Doi, Y.
Hashimoto and H. Miyachi
Bioorg. Med. Chem. 2006, 14(24), 8405-8414 |
"Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin"
O. Pasternak, G. D. Bujacz, Y. Fujimoto, Y. Hashimoto, F. Jelen, J. Otlewski,
M. M. Sikorski and M. Jaskolski
The Plant Cell 2006, 18, 2622-2634 |
"Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic
acid derivatives as class-selective histone deacetylase (HDAC) inhibitors"
C. Shinji, S. Maeda, K. Imai, M. Yoshida, Y. Hashimoto and H. Miyachi
Bioorg. Med. Chem. 2006, 14(22), 7625-7651 |
"Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient
mice results in the formation of ring sideroblasts and siderocytes "
O. Nakajima, S. Okano, H. Harada, T. Kusaka, X. Gao, T. Hosoya, N. Suzuki,
S. Takahashi and M. Yamamoto
Genes Cells 2006, 11, 685-700 |
"Diastereoselective Henry reaction catalyzed by guanidine-thiourea
bifunctional organocatalyst"
Y. Sohtome, N. Takemura, T. Iguchi, Y. Hashimoto and K. Nagasawa
Synlett 2006, 1, 144-146 |
"Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction
Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst "
Yoshihiro Sohtome, Yuichi Hashimoto and Kazuo Nagasawa
Eur. J. Org. Chem. 2006, 13, 2894-2897 |
"Recent progress of the medicinal chemistry research on peroxisome proliferator-activated receptor for the treatment of metabolic syndrome"
H. Miyachi
Current Bioactive Compound 2006, 2, 151-159 |
"糖尿病の薬物療法" （分担執筆）
宮地 弘幸
PPARをターゲットとした創薬 （編者: 難波光義、谷澤幸生） 2006, 226-229, 文光堂 |
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