2002年
"Conformation of ligands bound to the muscarinic acetylcholin receptor."
H. Furukawa, T. Hamada, M. K. Hayashi, T. Haga, H. Hirota, S. Yokoyama, K. Nagasawa, M. Ishiguro
Mol. Pharmacol., 62, 778-787, 2002. |
"Novel non-steroidal/non-anilide type androgen antagonists with isoxazolone
moiety."
T. Ishioka, A. Kubo, Y. Koiso, K. Nagasawa, A. Itai, Y. Hashimoto
Bioorg. Med. Chem., 10, 1555-1566, 2002. |
"Thalidomide and its analogues as cyclooxygenase inhibitors."
T. Noguchi, R. Shimazawa, K. Nagasawa, Y. Hashimoto
Bioorg. Med. Chem. Lett., 12, 1043-1046, 2002. |
"Total synthesis of crambescidine 359."
K. Nagasawa, A. Georgieva, H. Koshino, T. Nakata, T. Kita, Y. Hashimoto
Org. Lett., 4, 177-180, 2002. |
"Novel mannich-type nucleophilic substitution reaction with tertiary aromatic
amines."
H. Takahashi, N. Kashiwa, Y. Hashimoto, K. Nagasawa
Tetrahedron Lett., 43, 2935-2938, 2002. |
"Coordination of sodium cation to an oxygen function and olefinic double
bond to form molecular adduct ion in fast atom bombardment mass spectrometry."
N. Morisaki, H. Kobayashi, Y. Yamamura, M. Morisaki, K. Nagasawa, Y. Hashimoto
Chem. Pharm. Bull., 50, 935-940, 2002. |
"Nuclephilic substitution on 4-hydroxymethylanilines under neutral conditions
via aza quinone methide intermediate."
H. Takahashi, N. Kashiwa, H. Kobayashi, Y. Hashimoto, K. Nagasawa
Tetrahedron Lett., 43, 5751-5753, 2002. |
"C2-symmetric chiral pentacyclic guanidine: A novel phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate schiff base."
T. Kita, A. Georgieva, Y. Hashimoto, T. Nakata, K. Nagasawa
Angew. Chem., Int. Ed., 41, 2832-2834, 2002. |
"Novel retinoid X receptor antagonists: Specific inhibition of retinoid synergism in RXR-RAR heterodimer actions."
B. Takahashi, K. Ohta, E. Kawachi, H. Fukasawa, Y. Hashimoto, H. Kagechika
J. Med. Chem., 45, 3227-3330, 2002. |
"Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity."
H. Ohki, K. Hirotani, H. Naito, S. Ohsuki, M. Minami, A. Ejima, Y. Koiso Y. Hashimoto
Bioorg. Med. Chem. Lett., 12, 3191-3193, 2002. |
"Stereoselective synthesis of tricyclic guanidine, the key component of
the batzelladine alkaloids."
K. Nagasawa, T. Ishiwata, Y. Hashimoto, T. Nakata
Tetrahedron Lett., 43, 6383-6385, 2002. |
"Total synthesis of batzelladien D."
T. Ishiwata, T. Hino, H. Koshino, Y. Hashimoto, T. Nakata, K. Nagasawa
Org. Lett., 4, 2921-2924, 2002. |
"Synthesis of novel heteroatom-containing Vitamin D3 Analogs."
Y. Kato, K. Nagasawa, Y. Koiso, H. Kobayashi, Y. Hashimoto
Vitamin, 76, 151, 2002. |
"A new screening method for antimitotic substances and isolation of glycolipids
as stimulators of tubulin polymerization from Okinawa sponge pseudoceratina
sp.."
S. Meguro, M. Namikoshi, H. Kobayashi
J. Antibiot., 55, 256-262, 2002. |
"Inhibitors of microtubule assembly produced by the marine fungus strain
TUF 98F139 collected in Palau."
M. Namikoshi, S. Suzuki, S. Meguro, H. Kobayashi, Y. Mine, I. Kasuga
J. Tokyo Univ. Fish., 88, 1-6, 2002. |
"Distribution of marine filamentous fungi associated with marine sponges
in Coral Reefs of Palau and Bunaken Island, Indonesia. "
M. Namikoshi, K. Akano, H. Kobayashi, Y. Koike, A. Kitazawa, A. B. Rondonuwu, S. Prarasik
J. Tokyo Univ. Fish., 88, 15-20, 2002. |
"サリドマイド事件は防げたか --- 光学活性と催奇形性 ---"
橋本祐一
現代化学, No. 370, p64-65, 2002年, 1月号. |
"Structural development of biological response modifiers based on thalidomide."
Y. Hashimoto
Bioorg. Med. Chem., 10, 461-479, 2002. |
"サリドマイドのマルチ創薬テンプレートとしての活用---ドラマタイプ創薬の1例."
橋本祐一
Bioベンチャー, 2, 43-49, 2002. |
"Structural development of biological response modifiers based on retinoids and thalidomide."
Y. Hashimoto
Mini-Rev. Med. Chem., 2, 543-551, 2002. |
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