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発表論文 Publications2017Yagai T, Matsui S, Harada K, Inagaki FF, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M. Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree. PLoS One. 2017 Apr 7;12(4):e0175355. doi: 10.1371/journal.pone.0175355. eCollection 2017 PubmedKatsumata L, Miyajima A, Itoh T. Portal fibroblasts marked by the surface antigen Thy1 contribute to fibrosis in mouse models of cholestatic liver injury. Hepatology Communications, 2017 Mar 22, DOI: 10.1002/hep4.1023 Chao HM, Huang HX, Chang PH, Tseng KC, Miyajima A, Chern E. Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway. Oncotarget. 2017 Jan 10;8(2):2604-2616. doi: 10.18632/oncotarget.13733. Pubmed 2016Leclerc E, Kimura K, Shinohara M, Danoy M, Le Gall M, Kido T, Miyajima A, Fujii T, Sakai Y. Comparison of the transcriptomic profile of hepatic human induced pluripotent stem like cells cultured in plates and in a 3D microscale dynamic environment. Genomics. 2017 Jan;109(1):16-26. doi: 10.1016/j.ygeno.2016.11.008. Epub 2016 Nov 29. PubmedPassman AM, Low J, London R, Tirnitz-Parker JE, Miyajima A, Tanaka M, Strick-Marchand H, Darlington GJ, Finch-Edmondson M, Ochsner S, Zhu C, Whelan J, Callus BA, Yeoh GC. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells Int. 2016;2016:5702873. Epub 2016 Oct 3. Pubmed Kiniwa T, Enomoto Y, Terazawa N, Omi A, Miyata N, Ishiwata K, Miyajima A. NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10139-44. doi: 10.1073/pnas.1600112113. Epub 2016 Aug 22. Pubmed Kamimoto K, Kaneko K, Kok CY, Okada H, Miyajima A, Itoh T. Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling. Elife. 2016 Jul 19;5. pii: e15034. doi: 10.7554/eLife.15034. Pubmed 2015Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chern EY, Tanaka M, Miyajiama A. CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells. Stem Cell Reports. 2015 Oct 13;5(4):508-15. PubmedKaneko K, Kamimoto K, Miyajima A, Itoh T. Adaptive remodeling of the biliary architecture underlies liver homeostasis. Hepatology. 2015 Jun;61(6):2056-66. Pubmed Inagaki NF, Inagaki FF, Kokudo N, Miyajima A. Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy.J Hepatol. 2015 May;62(5):1141-7. doi: 10.1016/j.jhep.2014.12.010. Epub 2014 Dec 13. Pubmed Inagaki NF, Inagaki FF, Kokudo N, Miyajima A. Cell-based therapy for preventing postoperative adhesion and promoting regeneration after hepatectomy. J Hepatobiliary Pancreat Sci. 2015 Jul;22(7):524-30. doi: 10.1002/jhbp.247. Pubmed Komori T, Tanaka M, Furuta H, Akamizu T, Miyajima A, Morikawa Y. Oncostatin M is a potential agent for the treatment of obesity and related metabolic disorders: a study in mice. Diabetologia. 2015 Aug;58(8):1868-76. doi: 10.1007/s00125-015-3613-9. Pubmed Kok CY, Miyajima A, Itoh T. Adaptive remodeling of the biliary tree: the essence of liver progenitor cell expansion. J Hepatobiliary Pancreat Sci.. 2015 Jul;22(7):546-50. doi: 10.1002/jhbp.250. Pubmed 2014Sato F, Miyaoka Y, Miyajima A, Tanaka M. Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by modulatingadipogenesis and osteogenesis. PLoS One. 2014 Dec 31;9(12):e116209. Pubmed Miyajima A, Tanaka M, Itoh T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell. 2014 May 1;14(5):561-74. doi: 10.1016/j.stem.2014.04.010. Pubmed Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M. Nrf2 nhances cholangiocyte expansion in Pten-deficient livers. Mol Cell Biol. 2014 Mar;34(5):900-13. Pubmed Itoh T, Miyajima A. Liver regeneration by stem/progenitor cells. Hepatology. 2014 Apr;59(4):1617-26. Pubmed Yagai T, Miyajima A, Tanaka M. Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration. Am J Pathol. 2014 Aug;184(8):2250-9. Pubmed Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A. Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15.Eur J Immunol. 2014 Sep;44(9):2638-47. Pubmed Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y. Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. J Biol Chem. 2014 May 16;289(20):13821-37. doi: 10.1074/jbc.M113.542399. Pubmed 2013Gailhouste L., Gomez-Santos L., Kitagawa N., Kawaharada K., Tirion M., Kosaka N., Takahashi R., Shibata T., Miyajima A., and Ochiya T. MiR-148a Plays a Pivotal Role in the Liver by Promoting the Hepatospecific Phenotype and Suppressing the Invasiveness of Transformed Cells. Hepatology, 2013 Sep;58(3):1153-65. doi: 10.1002/hep.26422. PubmedKomori T., Tanaka M., Senba E., Miyajima A. and Morikawa Y. Lack of Oncostatin M receptor b leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J. Biol. Chem. 288, 21861-21875, 2013. Pubmed Miyaoka Y. and Miyajima A. To divide or not to divide: revisiting liver regeneration. Cell Division 8, 8, 2013. Pubmed Bando T., Morikawa Y., Hisaoka T., Komori T., Miyajima A., and Senba E. Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Neuroscience letters 548, 73-78, 2013. Pubmed Itoh T. and Miyajima A. Cellular Basis of Liver Regeneration. Hepatology. In press. Hinako M. Takase, Tohru Itoh, Seitaro Ino, Ting Wang, Takehiko Koji, Shizuo Akira, Yasuhiro Takikawa, and Atsushi Miyajima, (2013) FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev 2013 Jan 15. Pubmed Hinako M. Takase, Tohru Itoh, Seitaro Ino, Ting Wang, Takehiko Koji, Shizuo Akira, Yasuhiro Takikawa, and Atsushi Miyajima, (2013) FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev 2013 Jan 15. Pubmed 2012Tanimizu N., Kikkawa Y., Mitaka T. and Miyajima A. (2012) a1- and a5-Containing laminins regulate the development of bile ducts via b1-integrin signals. J. Biol. Chem. 287, 28586-28597. PubmedInagaki FF, Tanaka M, Inagaki NF, Yagai T, Sato Y, Sekiguchi K, Oyaizu N, Kokudo N, Miyajima A.(2012) Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells. Biochem Biophys Res Commun. 2012 Dec 1. Pubmed Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N.(2012) Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug 23. Pubmed Miyaoka Y., Ebato K., Kato H., Arakawa S., Shimizu S., and Miyajima A. Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Current Biology 22, 1166-1175, 2012. Pubmed Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A.(2012) Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A. 2012 Feb 27. Pubmed Kamiya A, Miyajima A.(2012) Mice with artificial human liver. Hepatology. 2012 Mar;55(3):974-7 Pubmed Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H.(2012) Hepatic stellate cell-derived delta-like homolog 1 (DLK1) in liver regeneration. J Biol Chem. 2012 Feb 1. Pubmed Tanaka M, Miyajima A. Identification and isolation of adult liver stem/progenitor cells. Methods Mol Biol. 2012;826:25-32. doi: 10.1007/978-1-61779-468-1_3. Pubmed 2011Itoh T., Tanaka M., and Miyajima A. Liver stem cells. Regenerative Medicine from protocol to patient (Springer 327 Ed. G. Steinhoff) p327-349. 2011.Tsukahara Y, Tanaka M, Miyajima A. (2011) TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development. PLoS One. 2011;6(12):e28607. Epub 2011 Dec 14. Pubmed Tanaka M, Miyajima A.(2011) Identification and isolation of adult liver stem/progenitor cells. Methods Mol Biol. 2012;826:25-32. Pubmed Saito H, Takeuchi M, Chida K, Miyajima A. (2011) Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro. PLoS One. 2011;6(12):e28209. Epub 2011 Dec 1. Pubmed Miyaoka Y, Kato H, Ebato K, Saito S, Miyata N, Imamura T, Miyajima A.(2011)Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms.Biochem J. 2011 Jul 21. [Epub ahead of print] Pubmed Tanaka M, Itoh T, Tanimizu N, Miyajima A.(2011) Liver stem/progenitor cells: their characteristics and regulatory mechanisms.J Biochem. 2011 Mar;149(3):231-9. Pubmed 2010Yamauchi S, Ito H, Miyajima A.(2010) IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11924-9. PubmedYanai H, Nakamura K, Hijioka S, Kamei A, Ikari T, Ishikawa Y, Shinozaki E, Mizunuma N, Hatake K, Miyajima A.(2010) Dlk-1, a cell surface antigen on fetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency.J Biochem. 2010 Jul;148(1):85-92. Pubmed Onitsuka I, Tanaka M, Miyajima A.(2010) Characterization and Functional Analyses of Hepatic Mesothelial Cells in Mouse Liver Development. Gastroenterology. 2010 Apr;138(4):1525-35, 1535.e1-6 Pubmed Miyaoka Y, Tanaka M, Imamura T, Takada S, Miyajima A.(2010) A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk). Development. 2010 Jan;137(1):159-67. Pubmed 2009Yamamoto Y, Kosaka N, Tanaka M, Koizumi F, Kanai Y, Mizutani T, Murakami Y, Kuroda M, Miyajima A, Kato T, Ochiya T.(2009) MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. Biomarkers. 2009 Nov;14(7):529-38. PubmedHirose Y, Itoh T, Miyajima A.(2009) Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells. Exp Cell Res. 2009 Sep 10;315(15):2648-57. Pubmed Tanaka M, Okabe M, Suzuki K, Kamiya Y, Tsukahara Y, Saito S, Miyajima A.(2009) Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver development. Mech Dev. 2009 Aug-Sep;126(8-9):665-76. Pubmed Okabe M, Tsukahara Y, Tanaka M, Suzuki K, Saito S, Kamiya Y, Tsujimura T, Nakamura K, Miyajima A.(2009) Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development. 2009 Jun;136(11):1951-60. Pubmed Esashi E, Ito H, Minehata KI, Saito S, Morikawa Y, Miyajima A.(2009) Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis. Eur J Immunol. 2009 Apr 21 Pubmed Tanimizu N, Miyajima A, Mostov KE.(2009) Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell. 2009 May;20(9):2486-94. Epub 2009 Mar 18. Pubmed Tomita T, Yamada A, Miyakoshi M, Kido T, Sheikh F, Srisodsai A, Miyajima A, Donnelly RP, Kimura S.(2009) Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner. Am J Respir Cell Mol Biol. 2009 May;40(5):620-30. Pubmed Chen YR, Sekine K, Nakamura K, Yanai H, Tanaka M, Miyajima A.(2009) Y-Box Binding Protein-1 Down-Regulates Expression of Carbamoyl Phosphate Synthetase-I by Suppressing CCAAT Enhancer-Binding Protein-Alpha Function in Mice. Gastroenterology. 2009 Mar 6. Pubmed Itoh T, Kamiya Y, Okabe M, Tanaka M, Miyajima A.(2009) Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response.FEBS Lett. 2009 Feb 18;583(4):777-81. Pubmed 2008Nonaka H, Watabe T, Saito S, Miyazono K, Miyajima A.(2008) Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling. Biochem Biophys Res Commun. 2008 Oct 17;375(2):256-60. Epub 2008 Aug 14. PubmedHams E, Colmont CS, Dioszeghy V, Hammond VJ, Fielding CA, Williams AS, Tanaka M, Miyajima A, Taylor PR, Topley N, Jones SA.(2008) Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. J Immunol. 2008 Aug 1;181(3):2174-80. Pubmed Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H.(2008) Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.Hepatology. 2008 Jul;48(1):252-64. Pubmed Suzuki K, Tanaka M, Watanabe N, Saito S, Nonaka H, Miyajima A.(2008) p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver. Gastroenterology. 2008 Jul;135(1):270-281 Pubmed Sugano Y, Takeuchi M, Hirata A, Matsushita H, Kitamura T, Tanaka M, Miyajima A.(2008) Junctional adhesion molecule-A, JAM-A, is a novel cell surface marker for long-term repopulating hematopoietic stem cells. Blood. 2008 Feb 1;111(3):1167-72 Pubmed 2007Saijou E, Itoh T, Kim KW, Iemura S, Natsume T, Miyajima A.(2007) Nucleo-cytoplasmic shuttling of the zinc finger protein EZI is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. J Biol Chem. 2007 Nov 2;282(44):32327-37 PubmedHamada T, Sato A, Hirano T, Yamamoto T, Son G, Onodera M, Torii I, Nishigami T, Tanaka M, Miyajima A, Nishiguchi S, Fujimoto J, Tsujimura T. Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats.Am J Pathol. 2007 Sep;171(3):872-81. Pubmed Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A.(2007) Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.EMBO J. 2007 Aug 8;26(15):3607-15. Pubmed Naiki T, Saijou E, Miyaoka Y, Sekine K, Miyajima A.(2007)TRB2, a mouse tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta. J Biol Chem. 2007 Aug 17;282(33):24075-82 Pubmed Nonaka H, Tanaka M, Suzuki K, Miyajima A.(2007) Development of murine sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Dev Dyn. 2007 Aug;236(8):2258-67 Pubmed Tanimizu N, Miyajima A.(2007) Molecular mechanism of liver development and regeneration. Int Rev Cytol. 2007;259:1-48. Pubmed Watanabe N, Tanaka M, Suzuki K, Kumanogoh A, Kikutani H, Miyajima A.(2007) Tim2 is expressed in mouse fetal hepatocytes and regulates their differentiation. Hepatology. 2007 Apr 26;45(5):1240-1249 Pubmed Tanimizu N, Miyajima A, Mostov KE.(2007) Liver Progenitor Cells Develop Cholangiocyte-type Epithelial Polarity in Three Dimensional Culture. Mol Biol Cell. 2007 Apr;18(4):1472-9 Pubmed Kobayashi T, Sato S, Takamiya S, Komaki-Yasuda K, Yano K, Hirata A, Onitsuka I, Hata M, Mi-Ichi F, Tanaka T, Hase T, Miyajima A, Kawazu S, Watanabe Y, Kita K.(2007)Mitochondria and apicoplast of Plasmodium falciparum: Behaviour on subcellular fractionation and the implication. Mitochondrion. 2007 Feb-Apr;7(1-2):125-32. Pubmed Nagawa F, Kishishita N, Shimizu K, Hirose S, Miyoshi M, Nezu J, Nishimura T, Nishizumi H, Takahashi Y, Hashimoto S, Takeuchi M, Miyajima A, Takemori T, Otsuka AJ, Sakano H.(2007) Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nat Immunol. 2007 Feb;8(2):206-13. Pubmed 2006Minehata K, Takeuchi M, Hirabayashi Y, Inoue T, Donovan PJ, Tanaka M, Miyajima A.(2006) Oncostatin m maintains the hematopoietic microenvironment and retains hematopoietic progenitors in the bone marrow.Int J Hematol. 2006 Nov;84(4):319-27. PubmedMiyaoka Y, Tanaka M, Naiki T, Miyajima A. (2006) Oncostatin M inhibits adipogenesis through the Ras/ERK and STAT5 signaling pathways. J Biol Chem. 2006 Dec 8;281(49):37913-20 Pubmed Ito H, Esashi E, Akiyama T, Inoue J, Miyajima A. (2006) IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus. International Immunology 18(8): 1253-63 Pubmed Ito T, Arimitsu N, Takeuchi M, Kawamura N, Nagata M, Saso K, Akimitsu N, Hamamoto H, Natori S, Miyajima A, Sekimizu K. (2006) Transcription Elongation Factor S-II Is Required for Definitive Hematopoiesis. Mol. Cell. Biol. 26: 3194-3203. Pubmed Sano H, Noguchi T, Miyajima A, Hashimoto Y, Miyachi H.(2006)Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.Bioorg Med Chem Lett. 2006 Jun 1;16(11):3068-72. Pubmed |
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