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発表論文 Publications2000Mukouyama Ys, Chiba N, Hara T, Okada H, Ito Y, Kanamaru R, Miyajima A, Satake M, Watanabe T. (2000) The AML1 Transcription Factor Functions to Develop and Maintain Hematogenic Precursor Cells in the Embryonic Aorta-Gonad-Mesonephros Region. Dev Biol 220:27-36.Ito Y., T. Matsui, A. Kamiya, T. Kinoshita, and A. Miyajima (2000) Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and Ras pathways during hepatic development. Hepatology 32,1370-1376. Kojima N., Kinoshita T., Kamiya A., Nakamura K. and Miyajima A. (2000) Cell-density-dependent regulation of hepatic development by a gp130-independent pathway。Biochem. Biophys. Res. Commun 277, 152-158. Miyajima A., T. Kinoshita, M. Tanaka, A. Kamiya, Y. Mukouyama and T. Hara. (2000) Roles of Oncostatin M in hematopoiesis and liver development. Cytokine and Growth Factor Reviews11:177-183. Yamada K, Ariyoshi K, Onishi M, Miyajima A, Hayakawa F, Towatari M, Saito H, Oka Y, Asano S, Nosaka T, and Kitamura T. (2000) Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int. J. Hematol. 71, 46-54. Hara T., Nakayama K. and Miyajima A. (2000) Hematopoietic Signal Transduction. Developmental Biology of Hematopoiesis (Ed. L. Zon, Oxford University Press) p258-268. Wang Y., Robledo O., Kinzie E., Blanchard F., Richards C., Miyajima A., and Baumann H. (2000) Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor. J. Biol. Chem. 275, 25273-25285. Ariyoshi K., Nosaka T., Yamada K., Onishi M., Oka Y., Miyajima A., and Kitamura T. (2000) Costitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275, 24407-24413. Oda A., Wakao H., Fujihara M., Ozaki K., Komatsu K., Tanaka S., Ikeda H., Miyajima A. and Ikebuchi K. (2000) Thrombopoietin and interleukin 2 induce association of Crk with STAT5. Biochem. Biophys. Res. Commun 278, 299-305. Tamura K., Kawaguchi T., Hara T., Sakamoto T., Tohei A., Miyajima A., Tsuchiya S., and Kogo H. (2000) Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell. Mol. Cell. Endocrinol. 170, 103-111. 1999Kitajima K, M. Kojima, K. Nakajima, S. Kondo, T. Hara, A. Miyajima, and T. Takeuchi. (1999) Definitive but not primitive hematopoiesis is impaired in jumonji. Blood. 93: 87-95.Tanaka M., T. Hara, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. Miyajima (1999) Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor b subunit. Blood. 93: 804-815. Chida D, O. Miura, A. Yoshimura, and A. Miyajima. (1999) Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: functional analysis of signaling molecules by retrovirus-mediated gene expression. Blood. 93:1567-1578. Miyajima A., T. Kinoshita, and T. Hara. (1999) Role of the common ? subunit of the IL-3, IL-5 and GM-CSF receptors. IL-5: From Molecule to Drug Taget for Asthma.(Ed. C. Sanderson) Marcel Dekker, Inc. New Yorlk, p225-239. Miyajima A., Y. Itoh, and T. Kinoshita (1999) Cytokine signaling for proliferation, survival, and death in hematopoietic cells. Int. J. Hematol 69, 137-146. Nakayama K., T. Hara, M. Hibi, T. Hirano and A. Miyajima (1999) The Novel Oncostatin M-Inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth. J. Biol.Chem. 274, 24766-24772. Mukouyama Y., N. Chiba, M. Mucenski, M. Satake, A. Miyajima, T. Hara and T. Watanabe. (1999) c-Myb Induces the Generation of Hematopoietic Cells during the Cultivation of the Murine Embryonic Aorta-Gonad-Mesonephros Region. Current Biol. 9, 833-836. Kamiya A., T. Kinoshita, Y. Ito, Y. Morikawa, E. Senba, K. Nakashima, T. Taga, K. Yoshida, T. Kishimoto, and A. Miyajima (1999) Fetal liver development requires a paracrine action of oncostatin M through gp130. EMBO J 18, 2127-2136. Kinoshita T., T. Sekiguchi, M.J Xu, Y. Ito, A. Kamiya, K. Tsuji, T. Nakahata, and A. Miyajima (1999) Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc. Natl. Acad. Sci. USA. 96; 7265-7270. Kurihara R., T. Kinoshita, A. Miyajima, T. Sinjyo, T. Yoshihara, T. Inukai, M. Masutani, K. Ozawa, A. T. Lock, and T. Inaba (1999) Regulation of cytokine-mediated cell survival through two distinct pathways, Ras/NFIL3(E4BP4) and Bcl-XL/Caspase-3, in murine IL-3 dependnet pro-B lymphocytes. Mol. Cell. Biol. 19:2754-2762. Hara T., Nakano Y., Tanaka M., Tamura K., Sekiguchi T., Minehata K., Copeland N.G., Jenkins N.A., Okabe M., Kogo H., Mukouyama Y., and Miyajima A. (1999) Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region. Immunity 11, 567-578. Aman M.J., Migone T-S., Sasaki A., Ascherman D.P., Zhu M-h., Soldaini E., Imada K., Miyajima A., Yoshimura A., and Leonard W.J. (1999) CIS associates with the interleukin-2 receptor b chain and inhibits interleukin-2-dependent signaling. J. Biol. Chem. 274, 30266-30272. Brizzi MF, Defilippi P, Rosso A, Venturino M, Garbarino G, Miyajima A, Silengo L, Tarone G, and Pegoraro L. (1999) Integrin-mediated adhesion of endothelial cells induces JAK2 and STAT5A activation: role in the control of c-fos gene expression. Mol Biol Cell 10:3463-3471. 1998Yamashita T., H. Wakao, A. Miyajima and S. Asano. (1998) Differentiation inducers modulate cytokine signaling pathways in a murine erythroleukemia cell line. Cancer Res. 58, 556-561.Furusawa, T., N. Yanai, T. Hara, A. Miyajima, and M. Obinata. (1998) Integrin-associated protein (IAP, also termed CD47) is involved in stroma-supported erythropoiesis. J. Biochem. 123, 101-106. Mukouyama, Y., T. Hara, M.J. Xu, K. Tamura, P.J. Donovan, H. Kogo, K. Tsuji, T. Nakahata, and A. Miyajima (1998) In vitro expansion of murine hematopoietic progenitors derived from the embryonic aorta gonad mesonephros region. Immunity 8, 105-114. Chida D., H. Wakao, and A. Miyajima (1998) Transcriptional regulation of the b-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules. Mol. Endocrinol. 12, 1792-1805. Hara, T., K. Tamura, Y. Mukouyama, H.J Kim, H. Kogo, P.J. Donovan and A.Miyajima (1998) Distinct roles of oncostatin M and leukemia inhibitory factor for the development of germ cells and testis. Develop. Biol. 201; 144-153. Hara, T. and A. Miyajima (1998) Cytokine receptors and signal transduction. Textbook of Malignant Haematology (Eds.; L. Degos, F. Herrman, D. Linch, and B. Lowenberg) Martin Dunitz Pu. p111-131. Uchida K, A. Yoshimura, K. Inazawa, H. Osada, T. Saito, T. Takahashi, A. Miyajima, and T. Takahashi. (1998) Molecular cloning of CISH, choromosomal assignment to 3p21.3 and analysis of expression in fetal and adult tissues. Cytogenet Cell Genet 78; 209-212. Onishi M., T. Nosaka, K. Misawa, A.L.F. Mui, D. Gorman, M. McMahon, A. Miyajima and T. Kitamura. (1998) Identification and characterization of a constitutive active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18; 3871-3879. Tamura K, H. Tamura, K. Kumasaki, A. Miyajima, T. Suga, and H. Kogo. (1998) Characterization of granulocyte-macrophage colony stimulating factor (GM-CSF) production in the ovary of gonadotropin-primed immature rodent. Mol. and Cell. Endocrinol. 142, 153-163. Morikawa Y, Nishida H, Misawa K, Nosaka T, Miyajima A, Senba E, Kitamura T (1998) Induction of synaptosomal-associated protein-23 kD (SNAP-23) by various cytokines. Blood 92; 129-135. Xu Mj, K. Tsuji K, T. Ueda, T. Mukouyama, T. Hara, FC. Yang, Y. Ebihara, S. Matsuoka, A. Manabe, A. Kikuchi, M . ItoM, A. Miyajima, T. Nakahata (1998) Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines. Blood 92:2032-2040. Ozaki K., A. Oda, H. Wakao, J. Rhodes, B.J. Druker, A. Ishida, M. Wakui, S. Okamoto, K. Morita, M. Handa, N. Komatsu, H. Ohashi, A. Miyajima, and Y. Ikeda. (1998) Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets. Blood, 92:4652-4662. 1997Wakao H., D. Chida, J. E. Damen, G. Krystal and A. Miyajima (1997) A possible involvement of STAT5 in erythropoietin-induced hemoglobin synthesis. Biochem. Biophys. Res. Commun. 234, 198-205.Iversen P.O., T.R. Hercus, B. Zacharakis, J. M. Woodcock, F. C. Stomski, S. Kumar, B. H. Nelson, A. Miyajima, and A. F. Lopez (1997) The apoptosis-inducing granulocyte-macrophage colony stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor and requires interleukin-1b-converting enzyme-like proteases. J. Biol. Chem. 272, 9877-9883. Matsumoto A., M. Masuhara, K. Mitsui, M. Yokouchi, M. Ohtsubo, H. Misawa, A. Miyajima, and A. Yoshimura (1997) CIS, a cytokine inducible SH2 protein, is a target of JAK-STAT5 pathway and modulates STAT5 activation. Blood 89, 3148-3154. Kinoshita, T., M. Shirouzu, A. Kamiya, K. Hashimoto, S. Yokoyama and A. Miyajima (1997) Raf/MAPK- and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3 dependent hematopoietic cells. Oncogene 15, 619-627. Ohta, T., T. Kinoshita, M. Naito, M. Masutani, T. Tsuruo and A. Miyajima (1997) Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. J. Biol. Chem.272, 23111-23116. Yamashita N., K. Shin-ya, M. Kitamura, H. Wakao, K. Furihata, K. Furihata, Y. Hayakawa, A. Miyajima and H. Seto (1997) Cytovaricin B, a new inhibitor of JAK-STAT signal transduction produced by Streptomyces torulosus. J. Antibiotics 50, 440-442. Chin H., H. Wakao, A. Miyajima, R. Kamiya, N. Miyasaka and O. Miura (1997) Erythropoietin induces tyrosine phosphorylation of the interleukin-3 receptor ? subunit (?IL3) and recruitment of Stat5 to possible Stat5-docking sites in bIL3. Blood 89, 4327-4336. Richards, C.D., C. Kerr, M. Tanaka, T. Hara, A. Miyajima, D. Pennica, F. Botelho, and C. M. Langdon (1997) Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1 and IL-6. J. Immunol. 159, 2431-2437. Renard, N., N. Harada, E. Callet-Bauchu, A. Miyajima, V. Duvert, J. Banchereau and S. Saeland (1997) Heterogeneity of the inhibitory effects of IL-4 in two novel B lineage acute lymphoblastic leukemina cell lines. Leukemina Research 21, 1037-1046. Ichihara, M., T. Hara, H.J. Kim, T. Murata, and A. Miyajima (1997) Oncostatin M and leukemia inhibitory factor do not utilize the same functional receptor in mice. Blood 90, 165-173. 1996Mui, A. L-F., Wakao H., Kinoshita T., Kitamura T., and Miyajima A. (1996) Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 15, 2425-2433.Yoshimura A., Ichihara, M., Kinjyo I., Moriyama M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hara T., and Miyajima A. (1996) Mouse Oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J. 15, 1055-1063. Itoh T., Muto A., Watanabe S., Miyajima A., Yokota T., and Arai K. (1996) Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling. J. Biol. Chem. 271, 7587-7592. OﾕFarrell A.M., Ichihara M., Mui A.L.F., and Miyajima A. (1996) Signaling pathways activated in a unique mast cell line where IL-3 supports survival and stem cell factor is required for a proliferative response. Blood 87, 3655-3668. Nishinakamura R., Miyajima A., Mee J., Tybulewicz, and Murray R. (1996) Hematopoiesis in mice lacking the entire granulocyte macrophage-colony stimulating factor/interleukin 3/interleukin 5 functions. Blood 88, 2458-2464. Hara T. and Miyajima A. (1996) Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. Stem Cells 14, 605-618. |
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