トップロゴ
トップへ研究内容へ発表論文へメンバー紹介へ写真へコンタクト
1990-19951996-20002001-20052006-


発表論文 Publications


2005

Noguchi T, Fujimoto H, Sano H, Miyajima A, Miyachi H, Hashimoto Y.(2005)Angiogenesis inhibitors derived from thalidomide.Bioorg Med Chem Lett. 2005 Dec 15;15(24):5509-13.

Kojima N, Shiojiri N, Sakai Y, Miyajima A.(2005)Expression of neuritin during liver maturation and regeneration.FEBS Lett. 2005 Aug 29;579(21):4562-6.

Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.(2005)Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.J Exp Med. 2005 Jul 4;202(1):169-79.

Bando T, Sekine K, Kobayashi S, Watabe AM, Rump A, Tanaka M, Suda Y, Kato S, Morikawa Y, Manabe T, Miyajima A.(2005)Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.Mol Cell Biol. 2005 May;25(10):4166-75.

Okaya A, Kitanaka J, Kitanaka N, Satake M, Kim Y, Terada K, Sugiyama T, Takemura M, Fujimoto J, Terada N, Miyajima A, Tsujimura T.(2005)Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes.Am J Pathol. 2005 Mar;166(3):709-19.

Doyonnas R, Nielsen JS, Chelliah S, Drew E, Hara T, Miyajima A, McNagny KM.(2005)Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.Blood. 2005 Jun 1;105(11):4170-8.

Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S.(2005)TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.Blood. 2005 Jun 1;105(11):4437-44.

Iwatsuki K, Tanaka K, Kaneko T, Kazama R, Okamoto S, Nakayama Y, Ito Y, Satake M, Takahashi S, Miyajima A, Watanabe T, Hara T.(2005)Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3.Oncogene. 2005 Feb 10;24(7):1129-37.

2004

Jiang J, Kojima N, Guo L, Naruse K, Makuuchi M, Miyajima A, Yan W, Sakai Y.(2004)Efficacy of engineered liver tissue based on poly-L-lactic acid scaffolds and fetal mouse liver cells cultured with oncostatin M, nicotinamide, and dimethyl sulfoxide.Tissue Eng. 2004 Sep-Oct;10(9-10):1577-86.

Nonaka H., Sugano S., and Miyajima A. (2004) Serial analysis of gene expression in sinusoidal endothelial cells from normal and injured mouse liver. Biochem. Biophys. Res. Commun. 324(1):15-24.

Tanimizu N., Saito H., Mostove K., and Miyajima A. (2004) Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J. Cell Sci. 117, 6425-6434.

Tanimizu N., Tsujimura T., Takahide K., Kodama T., Nakamura K., and Miyajima A. (2004) Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. Mech. Dev. Gene Exp. Pat. 5, 209-218.

Esashi E., Ito H., Ishihara H., Hirano T., Koyasu S., and Miyajima A. (2004) Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells. J. Immunol. 173, 4360-4367.

Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H. (2004) Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. Blood. 103(8): 3185-3191.

Shimizu A., Sasaki H., Aoya K., Yoshida M., Kato K., Heike Y., Ikarashi Y., Shirakawa K., Takaue Y., Miyajima A., Terada M., Nagai H., and Wakasugi H. (2004) The mouse natural killer T cell-associated antigen recognized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-1. Immunol. Letters 92, 227-235.

Takeuchi M. and Miyajima A. Hematopoiesis in Fetal Liver. Pluripotent Hematopoietic Stem Cells (Ed. J. Keller) ISBN: 1-58706-182-1 in press

Tanimizu N. and Miyajima A. (2004) Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J.Cell Sci. 117, 3165-3173.

Jiang J., N. Kojima, T. Kinoshita, A. Miyajima, W. Yan, and Y. Sakai (2004) Cultivation and induction of fetal liver cells in a poly-L-lactic acid scaffold. Mat. Eng. C. 24, 361-363.

Morikawa Y., Tamura S., Minehata K., Donovan P.V., Miyajima A., and Senba E. (2004) Essential function of oncostatin M in nociceptive neurons of dorsal root ganglia. J. Neuroscience. 24(8):1941-1947.

Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., and Miyajima A. (2004) Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J. Biol. Chem. 279(10):9190-9198.

Nakamura K and Miyajima A. (2004) Oncostatin M promotes differentiation of fetal hepatocytes in vitro and regulates liver regeneration in vivo. Frontier in hepatology: growth/differentiation and hepatocyte/HCC. (K. Okita Ed. Springer-Verlag) pp26-35.

Nakamura K., H. Nonaka, H. Saito, M. Tanaka, and A. Miyajima. (2004) Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology 39: 635-44.

2003

Tanimizu N., Nishikawa M., Saito H., Tsujimura T., and Miyajima A. (2003) Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J.Cell Sci. 116, 1775-1786.

Anzai H., A. Kamiya, H. Shirato, T. Takeuchi and A. Miyajima. (2003) Impaired differentiation of fetal hepatocytes in homozygous jumonji mice. Mech. Dev. 120, 791-800.

Tanaka M., Y. Hirabayashi, T. Sekiguchi, T. Inoue, M. Katsuki, and A. Miyajima. (2003) Targeted disruption of Oncostatin M receptor results in altered hematopoiesis. Blood 102, 3154-3162.

Tanaka M. and A. Miyajima. (2003) Oncostatin M, a multifunctional cytokine. Reviews of Physiology, Biochemistry and Pharmacology, 149, 39-52.

Esashi E., T. Sekiguchi, Ito H, S. Koyasu, and A. Miyajima. (2003) Cutting Edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes J. Immunol. 171: 2773-2777.

Hanada S, Kayano H, Jiang J, Kojima N, Miyajima A, Sakoda A, Sakai Y. (2003) Enhanced in vitro maturation of subcultivated fetal human hepatocytes in three dimensional culture using poly-L-lactic acid scaffolds in the presence of oncostatin M. Int J Artif Organs. 26(10):943-951.

Minegishi N, Suzuki N, Yokomizo T, Pan X, Fujimoto T, Takahashi S, Hara T, Miyajima A, Nishikawa S, Yamamoto M. (2003) Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood102(3):896-905.

Tamura S, Morikawa Y, Miyajima A, Senba E.(2003)Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.Eur J Neurosci. 2003 Jun;17(11):2287-98.

Tanaka M, Miyajima A.(2003)Oncostatin M, a multifunctional cytokine.Rev Physiol Biochem Pharmacol. 2003;149:39-52.

2002

Tamura S., Y. Morikawa, M. Tanaka, A. Miyajima and E. Senba (2002) Developmental expression pattern of oncostatin M receptor _ in mice. Mech Dev. 115,127-131.

Nakayama K, K-W. Kim, and A. Miyajima (2002) A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. EMBO J. 21, 6174-6184.

Matsui T., Kinoshita T., Morikawa Y., Tohya K., Katsuki M., Ito Y., Kamiya A., and Miyajina A. (2002) K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. EMBO J. 21, 1021-1030.

Matsui T., T. Kinoshita, T. Hirano, T.Yokota and A. Miyajima (2002) STAT3 down-regulates the expression of cyclin D during liver developmentJ. Biol.Chem. 277: 36167-36173.

Kamiya A., N. Kojima, T. Kinoshita, Y. Sakai and A. Miyaijma (2002) Maturation of fetal hepatocytes in vitro by extracellular matrices and Oncostatin M; Induction of tryptophan oxygenase. Hepatology 35, 1351-1359.

Kinoshita T and A. Miyajima (2002) Cytokine regulation of liver development. Biochimica et Biophysica Acta 1592, 303-312.

Enomoto H., K. Yoshida, Y. Kishima, T. Kinoshita, M. Yamamoto, A.D. Everett, A. Miyajima and H. Nakamura. (2002) Hepatoma-derived growth factor is highly exspressed in developing liver and promotes fetal hepatocyte proliferation. Hepatology36,1519- 1527.

Minehata K., Mukouyama Y., Sekiguchi T., Hara T., and Miyajima A. (2002) Macrophage-colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region. Blood 99, 2360-2368.

Takeuchi M., Sekiguchi T., Hara T., Kinoshita T., and Miyajima A. (2002) Cultivation of AGM-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances homing to the bone marrow. Blood 99,1190-1196.

Sakai Y, J. Jiang, N. Kojima, T.Kinoshita and A. Miyajima. (2002) Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotinamide, and dimethylsufoxide. Cell Transplantation, 11(5):435-41.

Jiang J., N. Kojima, T. Kinoshita, A. Miyajima, W. Yan and Y.Sakai. (2002) Cultivation of fetal liver cells in a three-dimensional poly-L-lactic acid scaffold in the presence of oncostatin M. Cell Transplantation,11(5):403-6.

Tamura S, Morikawa Y, Miyajima A, Senba E.(2002)Expression of oncostatin M in hematopoietic organs.Dev Dyn. 2002 Nov;225(3):327-31.

Tamura H, Okamoto S, Iwatsuki K, Futamata Y, Tanaka K, Nakayama Y, Miyajima A, Hara T.(2002)In vivo differentiation of stem cells in the aorta-gonad-mesonephros region of mouse embryo and adult bone marrow. Exp Hematol. 2002 Aug;30(8):957-66.

2001

Kamiya A., Kinoshita T., and Miyajima A. (2001) Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Letters 492, 90-94.

Shinjo T., Kurihara R., Inukai T., Hosoi H., Kinoshita T., Miyajima A., Houghton P.J., Look A. T., Ozawa K., and Inaba T. (2001) Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol. Cell. Bio. 21, 854-864.

Kinoshita T., Nagata K., Sorimachi N., Karasuyama H., Sekiguchi T., and Miyajima A. (2001) Oncostatin M suppresses generation of progenitors in fetal liver by inhibiting the hepatic microenvironment. Exp. Hematol. 29, 1091-1097.

Murakami R., Tomikawa T., Shin-ya K., Shinozaki J., Kajiura T., Kinoshita T., Miyajima A., Seto H., and Hayakawa Y. (2001) Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. 1. Production, isolation, and biological activity. J. Antibiotics 54, 710-713.

Nishikawa M, Tahara T, Hinohara A, Miyajima A, Nakahata T, Shimosaka A.(2001) Role of the microenvironment of the embryonic aorta-gonad-mesonephros region in hematopoiesis. Ann N Y Acad Sci. 2001 Jun;938:109-16.

Tamura K, Kawaguchi T, Hara T, Takatoshi S, Tohei A, Miyajima A, Seishi T, Kogo H.(2001)Abstract Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell. Mol Cell Endocrinol. 2000 Dec 22;170(1-2):103-11.