欧文 English
Jin J, Ogawa T, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, and Shiroguchi K.
Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes.
Proc Natl Acad Sci USA. 120(1):e2210283120, 2023
Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, and Okazaki T.
Binding of LAG-3 to stable peptide-MHCII limits T cell function and suppresses autoimmunity and anti-cancer immunity.
Immunity, 55(5):912-924.e8, 2022
Sugiura D, Okazaki IM, Maeda TK, Maruhashi T, Shimizu K, Arakaki R, Takemoto T, Ishimaru N, and Okazaki T.
PD-1 agonism by anti-CD80 antibody inhibits T cell activation and alleviates autoimmunity.
Nature Immunology, 23(3):399-410, 2022
Sugiura D, Shimimzu K, Maruhashi T, Okazaki IM, and Okazaki T.
T cell-intrinsic and -extrinsic regulation of PD-1 function.
International Immunology, 33(12):693-698, 2021
Kanda Y, Okazaki T, and Katakai T.
Motility dynamics of T cells in tumor-draining lymph nodes: a rational indicator of antitumor response and immune checkpoint blockade.
Cancers, 13(18):4616, 2021
Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takemoto T, and Okazaki T.
PD-1 preferentially inhibits the activation of low affinity T cells.
Proc Natl Acad Sci USA. 118(35):e2107141118, 2021
Maruhashi T, Sugiura D, Okazaki IM, and Okazaki T.
LAG-3: from molecular functions to clinical applications.
J Immunother Cancer, 8(2):e001014, 2020.
Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, and Okazaki T.
PD-1 imposes qualitative control of cellular transcriptomes in response to T cell activation.
Molecular Cell, 77(5):937-950, 2020
Maeda N, Maruhashi T, Sugiura D, Shimizu K, Okazaki IM, and Okazaki T.
Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells.
Journal of Biological Cheistry, 294(52): 19896-19906, 2019
Okazaki T and Okazaki IM.
Stimulatory and inhibitory co-signals in autoimmunity.
Advances in Experimental Medicine and Biology, 1189: 213-232, 2019
Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, and Okazaki T.
PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions.
Journal of Autoimmunity, 105: 102296, 2019
Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, and Okazaki T.
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
Science, 364(6440): 558-566, 2019
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, and Okazaki T.
PD-1 primarily targets TCR signal in the inhibition of functional T cell activation.
Frontiers in Immunology, 10: 630, 2019
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, and Okazaki T.
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Journal of Biological Chemistry, 294(15): 6017-6026, 2019
Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, and Okazaki T.
PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.
Biochemical and Biophysical Research Communications, 511(3): 491-497, 2019
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, and Okazaki T.
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Nature Immunology, 19(12): 1415-1426, 2018
Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, and Matsumoto M.
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).
Journal of Autoimmunity, 86: 75-92, 2018
Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, and Irimura T.
Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.
Cancer Science, 107(2): 189-202, 2016
Okazaki T, Chikuma S, Iwai Y, Fagarasan S, and Honjo T.
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
Nature Immunology, 14(12): 1212-1218, 2013
Iwamoto S, Kido M, Aoki N, Nishiura H, Maruoka R, Ikeda A, Okazaki T, Chiba T, and Watanabe N.
TNF-α is essential in the induction of fatal autoimmune hepatitis in mice through upregulation of hepatic CCL20 expression.
Clinical Immunology, 146(1): 15-25, 2013
Sugino Y, Nishikawa N, Yoshimura K, Kuno S, Hayashi Y, Yoshimura N, Okazaki T, Kanematsu A, and Ogawa O.
BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis.
Scientific Reports, 2: 317, 2012
Jin HT, Ahmed R, and Okazaki T.
Role of PD-1 in Regulating T-Cell Immunity.
Current Topics in Microbiology and Immunology, 350:17-37, 2011
Iwamoto S, Kido M, Aoki N, Nishiura H, Maruoka R, Ikeda A, Okazaki T, Chiba T, and Watanabe N.
IFN-g is reciprocally involved in the concurrent development of organ-specific autoimmunity in the liver and stomach.
Autoimmunity, 45(2): 186-198, 2012
Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, and Takeda K.
Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis.
Proceedings of the National Academy of Sciences of the USA, 109(13): 5010-5015, 2012
Chikuma S, Suita N, Okazaki IM, Shibayama S, and Honjo T.
TRIM28 prevents autoinflammatory T cell development in vivo.
Nature Immunology, 13(6): 596-603, 2012
Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, Kato Y, Fagarasan S, Muramatsu M, Eto T, Hioki K, and Honjo T.
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Journal of Experimental Medicine, 208(2): 395-407, 2011
Aoki N, Kido M, Iwamoto S, Nishiura H, Maruoka R, Tanaka J, Watanabe T, Tanaka Y, Okazaki T, Chiba T, and Watanabe N.
Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.
Gastroenterology, 140(4): 1322-1333, 2011
Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, and Honjo T.
Interferon a directly promotes programmed-cell-death-1 transcription and limits the duration of T cell-mediated immunity.
Journal of Immunology, 186(5): 2772-2779,2011
Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, and Honjo T.
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Proceedings of the National Academy of Sciences of the USA, 108(19): 7920-7925, 2011
Sakai S, Kawamura I, Okazaki T, Tsuchiya K, Uchiyama R, and Mitsuyama M.
PD-1-PD-L1 pathway impairs T(h)1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guérin.
International Immunology, 22(9): 915-925, 2010
Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani S, Tanaka Y, Minato N, and Kumagai S.
Anti-PD-1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.
Journal of Immunology, 184(5): 2337-2347, 2010
Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, Hiai H, Honjo T, and Okazaki T.
PD-1 deficiency results in the development of fatal myocarditis in MRL mice.
International Immunology, 22(6): 443-452, 2010
Hino S, Kabashima K, Kato Y, Yagi H, Nakamura M, Honjo T, Okazaki T, and Tokura Y.
Tumor cell expression of programmed cell death 1 ligand 1 is a prognostic factor for malignant melanoma.
Cancer, 116(7): 1757-1766, 2010
Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida Y, Shibayama S, Okazaki T, and Honjo T.
PD-1-mediated suppression of IL-2 production induces CD8+ T-cell anergy in vivo.
Journal of Immunology, 182(11): 6682-6689, 2009
Jiang F, Yoshida T, Nakaki F, Terawaki S, Chikuma S, Kato Y, Okazaki IM, Honjo T, and Okazaki T.
Identification of QTLs that modify peripheral neuropathy in NOD.H2b–Pdcd1–/– mice.
International Immunology, 21(5): 499-509, 2009
Sugita S, Usui Y, Horie S, Futagami Y, Aburatani H, Okazaki T, Honjo T, Takeuchi M, and Mochizuki M.
T cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions.
Investigative Ophthalmology & Visual Science, Jun;50(6): 2862-70, 2009
Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, and Honjo T.
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
Proceedings of the National Academy of Sciences of the USA, 106(52): 22375-22380, 2009
Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, and Honjo T.
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
International Immunology, 21(8): 947-955, 2009
Shivarov V, Shinkura R, Doi T, Begum NA, Nagaoka H, Okazaki IM, Ito S, Nonaka T, Kinoshita K, and Honjo T.
Molecular mechanism for generation of antibody memory.
Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1517): 569-575, 2009
Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki IM, Honjo T, Chiba T, and Kinoshita K.
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.
Oncogene, 28(4): 469-478, 2009
Kido M, Watanabe N, Okazaki T, Akamatsu T, Tanaka J, Saga K, Nishio A, Honjo T, and Chiba T.
Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.
Gastroenterology, 135(4): 1333-43, 2008
Yoshida T, Jiang F, Honjo T, and Okazaki T.
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes on NOD background.
Proceedings of the National Academy of Sciences of the USA, 105(9): 3533-3538, 2008
Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, and Garboczi DN.
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
Proceedings of the National Academy of Sciences of the USA, 105(8): 3011-3016, 2008
Green KA, Okazaki T, Honjo T, Cook WJ, and Green WR.
The programmed death-1 and interleukin-ao pathway play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome.
Journal of Virology, 82(5): 2456-2469, 2008
Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, and Chiba T.
Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.
International Journal of Cancer, 123(12): 2735-2740, 2008
Okazaki T and Honjo T.
PD-1 and PD-1 ligands: from discovery to clinical application.
International Immunology, 19(7): 813-824, 2007
Terawaki S, Tanaka Y, Nagakura T, Hayashi T, Shibayama S, Muroi K, Okazaki T, Mikami B, Garboczi DN, Honjo T, and Minato N.
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
International Immunology, 19(7): 881-890, 2007
Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, and Fujii S.
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Proceedings of the National Academy of Sciences of the USA, 104(9): 3360-3365, 2007
Okazaki IM, Kotani A, and Honjo T.
Role of AID in tumorigenesis.
Advances in Immunology, 94: 245-273, 2007
Endo Y, Marusawa H, Kinoshita K, Morisawa T, Sakurai T, Okazaki IM, Watashi K, Shimotohno K, Honjo T, and Chiba T.
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.
Oncogene, 26(38): 5587-5595, 2007
Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T, and Chiba T.
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
Nature Medicine, 13(4): 470-476, 2007
Shinkura R, Okazaki IM, Muto T, Begum NA, and Honjo T.
Regulation of AID function in vivo.
Advances in Experimental Medicine and Biology, 596: 71-81, 2007
Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D, and Honjo T.
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.
Proceedings of the National Academy of Sciences of the USA, 104(5): 1616-1620, 2007
Kou T, Marusawa H, Kinoshita K, Endo Y, Okazaki IM, Ueda Y, Kodama Y, Haga H, Ikai I, and Chiba T.
Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.
International Journal of Cancer, 120(3): 469-476, 2007
Okazaki T and Honjo T.
The PD-1-PD-L pathway and immunological tolerance.
Trends in Immunology, 27(4): 195-201, 2006
Okazaki T and Honjo T.
Rejuvenating exhausted T cells during chronic viral infection.
Cell, 124(3): 459-461, 2006
Muto T, Okazaki IM, Yamada S, Tanaka Y, Kinoshita K, Muramatsu M, Nagaoka H, and Honjo T.
Negative regulation of activation-induced cytidine deaminase in B cells.
Proceedings of the National Academy of Sciences of the USA, 103(8): 2752-2757, 2006
Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV and Honjo T.
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
Journal of Experimental Medicine, 202(12): 1643-1648, 2005
Kobayashi M, Kawano S, Hatachi S, Kurimoto C, Okazaki T, Iwai Y, Honjo T, Tanaka Y, Minato N, Komori T, Maeda S, and Kumagai S.
Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome.
Journal of Rheumatology, 32(11): 2156-2163, 2005
Okazaki T and Honjo T.
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.
Trends in Molecular Medicine, 11(5): 322-326, 2005
Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, and Honjo T.
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Proceedings of the National Academy of Sciences of the USA, 102(33): 11823-11828, 2005
Okazaki T and Wang J.
PD-1/PD-L pathway and autoimmunity.
Autoimmunity, 38(7): 353-357, 2005
Probst HC, McCoy K, Okazaki T, Honjo T, and van den Broek M.
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.
Nature Immunology, 6(3): 280-286, 2005
Kotani A, Okazaki IM, Muramatsu M, Kinoshita K, Begum NA, Nakajima T, Saito H, and Honjo T.
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.
Proceedings of the National Academy of Sciences of the USA, 102(12): 4506-11, 2005
Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, Ishida M, Hiai H, Matsumori A, Minato N, and Honjo T.
Autoantibodies against cardiac troponin I are responsible for the dilated cardiomyopathy in PD-1 deficient mice.
Nature Medicine, 9(12): 1477-1483, 2003
Iwai Y, Terawaki S, Ikegawa M, Okazaki T, and Honjo T.
PD-1 inhibits antiviral immunity at the effector phase in the liver.
Journal of Experimental Medicine, 198(1): 39-50, 2003
Okazaki IM, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, and Honjo T.
Constitutive expression of AID leads to tumorigenesis.
Journal of Experimental Medicine, 197(9): 1173-1181, 2003
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, and Minato N.
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Proceedings of the National Academy of Sciences of the USA, 99(19): 12293-12297, 2002
Kanazawa N, Okazaki T, Nishimura H, Tashiro K, Inaba K, and Miyachi Y.
DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif.
Journal of Investigative Dermatology, 118(2): 261-266, 2002
Okazaki T, Iwai Y, and Honjo T.
New regulatory co-receptors: inducible co-stimulator and PD-1.
Current Opinion in Immunology, 14(6): 779-782, 2002
Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N, and Honjo T.
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.
Immunology Letters, 84(1): 57-62, 2002
Iwai Y, Okazaki T, Nishimura H, Kawasaki A, Yagita H, and Honjo T.
Microanatomical localization of PD-1 in human tonsils.
Immunology Letters, 83(3): 215-220, 2002
Yoshikawa K, Okazaki IM, Eto T, Kinoshita K, Muramatsu M, Nagaoka H, and Honjo T.
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.
Science. 296(5575): 2033-2036, 2002
Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, and Honjo T.
The AID enzyme induces class switch recombination in fibroblasts.
Nature. 416(6878): 340-345, 2002
Okazaki T, Maeda A, Nishimura H, Kurosaki T, and Honjo T.
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
Proceedings of the National Academy of Sciences of the USA, 98(24): 13866-133871, 2001
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, and Freeman GJ.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Nature Immunology, 2(3): 261-268, 2001
Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, and Honjo T.
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
Science, 291(5502): 319-322, 2001
Okazaki T, Iwai Y, Nishimura H, and Honjo T.
The regulation of PD-1/PD-L1 pathway and autoimmune diseases.
In: Activating and inhibitory immunoglobulin-like receptors, Eds. Cooper, M.D., Takai, T. and Ravetch, J.V. (Springer-Verlag, Tokyo), 211-214, 2001
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, and Honjo T.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Journal of Experimental Medicine, 192(7): 1027-1034, 2000
Mandelboim O, Kent S, Davis DM, Wilson SB, Okazaki T, Jackson R, Hafler D, and Strominger JL.
Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells.
Proceedings of the National Academy of Sciences of the USA, 95(7): 3798-3803, 1998
Minoguchi S, Taniguchi Y, Kato H, Okazaki T, Strobl LJ, Zimber-Strobl U, Bornkamm GW, and Honjo T.
RBP-L, a transcription factor related to RBP-Jkappa.
Molecular and Cellular Biology, 17(5): 2679-2687, 1997
Satoh N, Ogawa Y, Katsuura G, Tsuji T, Masuzaki H, Hiraoka J, Okazaki T, Tamaki M, Hayase M, Yoshimasa Y, Nishi S, Hosoda K, and Nakao K.
Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats.
Endocrinology, 138(3): 947-954, 1997
Okazaki T, Ogawa Y, Tamura N, Mori K, Isse N, Aoki T, Rochelle JM, Taketo MM, Seldin MF, and Nakao K.
Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene.
Genomics, 37(3): 395-399, 1996
Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Mori K, Tamura N, Hosoda K, and Nakao K.
Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.
Biochemical and Biophysical Research Communications, 225(1): 75-83, 1996
Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S, Hosoda K, Inazawa J, and Nakao, K.
Structural organization and chromosomal assignment of the human obese gene.
Journal of Biological Chemistry, 270(46): 27728-27733, 1995
Ogawa Y, Masuzaki H, Isse N, Okazaki T, Mori K, Shigemoto M, Satoh N, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, and Nakao K.
Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.
Journal of Clinical Investigation, 96(3): 1647-1652, 1995
Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, and Nakao K.
Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue.
Diabetes, 44(7): 855-858, 1995
和文 Japanese
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丸橋拓海 :
免疫チェックポイント分子LAG-3によるTh細胞応答の選択的な抑制機構
日本免疫学会ニュースレター, 27(2): 14, 2019
丸橋拓海, 岡崎 拓 :
LAG-3によるヘルパーT細胞応答の選択的な抑制機構
実験医学, 37(6): 942-945, 2019
岡崎 拓 :
表紙の顔・本庶佑,
学術の動向, 24(2): 3, 2019
岡崎 拓 :
PD-1研究の動向,
学術の動向, 24(2): 8-14, 2019
岡崎 拓 :
免疫チェックポイント分子LAG-3メカニズム解明から治療法を目指す
日経サイエンス49(1): 88-89, 2019
岡崎 拓 :
PD-1研究の歴史と今後の展望
科学, 89(2): 117-124, 2019
岡崎 拓 :
本庶佑先生のノーベル医学・生理学賞ご受賞によせて
JSICRニュースレター, 46: 32-34, 2018
丸橋拓海, 岡崎 拓 :
免疫チェックポイント分子LAG-3はMHCクラスII分子を構造に依存的に認識することによりヘルパーT細胞の応答を選択的に抑制する
ライフサイエンス新着論文レビュー, 2018, doi: 10.7875/first.author.2018.116
岡崎 拓 :
ダイアの原石
実験医学, 36(19): 3259-3261, 2018
岡崎 拓, 岡崎一美 :
免疫寛容を標的とした抗体医薬によるがん免疫療法
実験医学, 36(11): 1836-1840, 2018
岡崎 拓 :
システム免疫学
炎症と免疫, 2017, 25(1), pp1-2.
岡崎 拓, 岡崎 一美 :
抑制性免疫補助受容体を標的としたがん免疫療法の基礎研究
医学のあゆみ, Vol.256, No.7, 789〜792頁, 2016年2月.
岡崎 拓, 岡崎 一美 :
抑制性免疫補助受容体PD-1によるがんと自己免疫の制御
生化学, Vol.87, No.6, 693〜704頁, 2015年12月.
岡崎 拓, 岡崎 一美 :
PD-1と自己免疫疾患
実験医学, Vol.33, No.12, 1935〜1940頁, 2015年7月.
岡崎 拓 :
免疫応答のチェックポイント
炎症と免疫, Vol.23, No.1, 1〜2頁, 2015年1月.
岡崎 拓 :
PD-1による免疫抑制機構とその異常による自己免疫疾患
細胞工学. 33(10): 1032-1037, 2014
岡崎 拓, 岡崎一美 :
免疫抑制受容体分指標的(PD-1とその関連分子)
炎症と免疫. 21(3): 189-194, 2013
岡崎一美, 岡崎 拓 :
癌、自己免疫病とPD-1.
医学のあゆみ. 245(3): 12353-12357, 2013
岡崎 拓, 岡崎一美 :
末梢性免疫寛容におけるPD-1とLAG-3の相乗性
感染・炎症・免疫. 41(4): 329-331, 2012
岡崎 拓 :
PD-1欠損マウス
モデル動物利用マニュアル, 疾患モデルの作製と利用—免疫疾患. pp80-86, 株式会社 エル・アイ・シー, 2011年6月30日発行
岡崎 拓, 岡崎一美 :
PD-1分子による免疫応答の制御
Medical Science Digest. 11月号, 2010
吉田 卓, 岡崎 拓 :
PD-1欠損と自己免疫感受性遺伝子
炎症と免疫, 15, 731-736 , 2007
岡崎 拓 :
PD-1と自己免疫疾患
Molecular Medicine増刊号 免疫2005, 41, 327-333, 2005
岡崎 拓, 本庶 佑 :
PD-1と自己免疫疾患
最新医学, 59, 1668-1672, 2004
岡崎 拓, 本庶 佑 :
PD-1欠損マウスに発症する拡張型心筋症は、心筋型トロポニンIに対する自己抗体の異常産生が原因である
医学のあゆみ, 208, 944-945, 2004
岡崎一美、村松正道、本庶 佑 :
AIDによる抗体分子多様化のメカニズム
学術月報, 56(10): 1075-1079, 2003
岡崎 拓, 本庶 佑 :
PD-1欠損マウスと免疫異常
Annual Review 免疫, 298-305, 2002
岡崎 拓, 小川佳宏, 田村尚久, 中尾一和 :
アドレノメデュリンの遺伝子構造と染色体部位
医学のあゆみ, 184, 10-14, 1998