Okazaki Lab

May 25, 2023
IQB seminar
Dr. Jean Hausser, Karolinska Institute, “NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology"

Apr, 2023
Zhiwen Wu, Emi Matsuda, Maika Nagata, and Annie Ou joined our laboratory.

Dec, 2022
Takumi Maruhashi received the best poster award in the 51st Annual Meeting of the Japanese Society for Immunology.
JSI site

Dec 27, 2022
Jin J, Ogawa T, Hojo N, Kryukov K, Shimizu K, Ikawa T, Imanishi T, Okazaki T, and Shiroguchi K.
Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes.
Proc Natl Acad Sci USA., 120(1):e2210283120, 2023
Journal site

Oct, 2022
Dawei Chen joined our laboratory.

Sep, 2022
Chihiro Sato was adopted as a JSPS research fellow (DC1) from April, 2023.

Apr, 2022
Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, and Okazaki T.
Binding of LAG-3 to stable peptide-MHCII limits T cell function and suppresses autoimmunity and anti-cancer immunity.
Immunity, 55(5):912-924.e8, 2022
Journal site

Apr, 2022
Ryuki Abiru received a scholarship from the Tadamitsu Kishimoto Kibou project by the Japanese Society for Immunology.
JSI site

Apr, 2022
Chihiro Sato received a scholarship from the SPRING GX project.

Apr, 2022
Chihiro Sato and Shimpei Matsumi joined our laboratory.

Feb 10, 2022
Sugiura D, Okazaki IM, Maeda TK, Maruhashi T, Shimizu K, Arakaki R, Takemoto T, Ishimaru N, and Okazaki T.
PD-1 agonism by anti-CD80 antibody inhibits T cell activation and alleviates autoimmunity.
Nature Immunology, Epub ahead of print
Journal site

New and Views in Nature Immunology
Journal site

Research Highlight in Nature Reviews Rheumatology
Journal site

Nov 2021
Ryuki Abiru received a scholarship from the SPRING GX project.
project site

Nov 1, 2021
Sakamoto joined as a technical staff.

Oct 1, 2021
Sugiura D, Shimizu K, Mruhashi T, Okazaki IM, and Okazaki T.
T cell-intrinsic and -extrinsic regulation of PD-1 function.
International Immunology, 33(12):693-698, 2021
Journal site

Sep 15, 2021
Kanda Y, Okazaki T, and Katakai T..
Motility dynamics of T cells in tumor-draining lymph nodes: a rational indicator of antitumor response and immune checkpoint blockade.
Cancers, 13(18):4616, 2021
Journal site

Sep 27, 2021
Taisuke Narazaki was adopted as a JSPS research fellow (DC1) from April, 2022.

Nov 1, 2021
Shu-Chun Chiu joined as a technical staff.

Aug 25, 2021
Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takemoto T, and Okazaki T.
PD-1 preferentially inhibits the activation of low affinity T cells.
Proc Natl Acad Sci U S A. 118(35): e2107141118, 2021
Journal site

Apr 14, 2021
Taku Okazaki received the Awards for Science and Technology in Research Category of The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology of Japan

Dec 8, 2020
Takumi Maruhashi received the Young Investigator Award of the Japanese Society for Immunology.

Sep 13, 2020
Maruhashi T, Sugiura D, Okazaki IM, and Okazaki T.
LAG-3: from molecular functions to clinical applications.
J Immunother Cancer, 8(2): e001014, 2021
Journal site

Jan 15, 2020
Shimizu K et al. Molecular Cell (2019) was highlighted by ACIR.
Journal site

Jan 8, 2020
Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, and Okazaki T
PD-1 imposes qualitative control of cellular transcriptomes in response to T cell activation.
Molecular Cell, Epub ahead of print
Journal site

Dec 13, 2019
Joint seminar with Prof. Shohei Hori (Graduate School of Pharmaceutical Sciences).
Dr. Dietmar Zehn, Technical University of Munich, “InTOXication causes T-cell exhaustion in chronic infection.”
Dr. Pere Santamaria, University of Calgary, “Peptide-MHC-based nanomedicines for the treatment of autoimmune disease: engineering, mechanisms and diseases.”

Dec 12, 2019
Daisuke Sugiura received the Young Investigator Award of the Japanese Society for Immunology.

Dec 10, 2019
Daisuke Sugiura and Takumi Maruhashi received the Tokushima University President Award for young scientists.

Nov 13, 2019
Maeda N, Maruhashi T, Sugiura D, Shimizu K, Okazaki IM, and Okazaki T.
Glucocorticoids potentiate the inhibitory capacity of PD-1 by up-regulating its expression on T cells.
Journal of Biological Chemistry, Epup ahead of print
Journal site

Nov, 2019
Natsumi Maeda received the Kouraku Award.

Nov 1, 2019
Okazaki Lab has moved to the Institute for Quantitative Biosciences, The University of Tokyo.

Jul, 2019
Natsumi Maeda received the Yoshimitsu Otsuka Scholarship.

Jul 2, 2019
Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, and Okazaki T.
PD-1 aborts the activation trajectory of autoreactive CD8 T cells to prohibit their acquisition of effector functions.
Journal of Autoimmunity, Epub ahead of print
Journal site

Jul, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Cancer Discovery.

Journal site

May 20, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Nature Immunology.

Journal site

May 8, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by ACIR.

Journal site

Apr 18, 2019
Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, and Okazaki T.
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
Science, 364(6440):558-566 (2019)
Journal site

Apr, 2018
Natsumi Maeda received the Katsunuma Scholarship.

Mar 29, 2019
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, and Okazaki T.
PD-1 primarily targets TCR signal in the inhibition of functional T cell activation.
Frontiers in Immunology, 10:630, 2019
Journal site

Mar 6, 2019
Maeda TK et al., J Biol Chem, 294(15): 6017-6026 was highlighted by ACIR
Journal site

Feb, 2019
Two medical students (Jun Ikubo and Taisuke Yamamoto) have joined our laboratory.

Feb 13, 2019
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, and Okazaki T.
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Journal of Biological Chemistry, 294(15): 6017-6026
PubMed

Feb 13, 2019
Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, and Okazaki T.
PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.
Biochemical and Biophysical Research Communications, 511(3):491-497, 2019
PubMed

Jan, 2019
Takumi Maruhashi was awarded the Oka Prize.

Nov 16, 2018
News & Views on Maruhashi et al. (Nature Immunology, 19:1415-1426, 2018） by Drs. Lui and Davis. "LAG-3: a very singular immune checkpoint"
Journal site

Oct 22, 2019
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, and Okazaki T.
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Nature Immunology, 19:1415-1426, 2018
PubMed

Oct 1, 2018
Dr. Tasuku Honjo, the mentor of Okazaki IM and Okazaki T, has been announced to receive the Nobel Prize in physiology or medicine.

Jun, 2018
A research project "Singularity biology" has been started. This project is supported by the Grant-in-Aid by the Japan Society for the Promotion of Science for Scientific Research on Innovative Areas.
http://singularity-bio.jp/eng/

Jun 30, 2018
Reina Mizuno received the best presentation award in the 17th Shikoku Immunology Forum.

Apr, 2017
Natsumi Maeda received the Katsunuma Scholarship.

Mar, 2018
Ryuki Abiru joined our group.
Two medical students (Riko Okano and Mitsuki Shimizu) have joined our laboratory.

Feb, 2018
Reina Mizuno was awarded the
Kouraku Prize.