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1) 原著論文
Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A.
Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous
sclerosis and neurodegenerative diseases.
Cell Reports 7: 1636-1639 (2014)
Kingsbury JM, Sen ND, Maeda T, Heitman J, Cardenas ME.
Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1
signaling to control cell growth in Saccharomyces cerevisiae.
Genetics, 196: 1077-1089 (2014)
Hericourt F, Chefdor F, Bertheau L, Tanigawa M, Maeda T, Guirimand G, Courdavault V, Larcher M, Depierreux C, Benedetti H, Morabito D,
Brignolas F, Carpin S.
Characterization of histidine-aspartate kinase HK1 and identification of
histidine phosphotransfer proteins as potential partners in a Populus multistep
phosphorelay.
Physiol Plant. 149： 188-199 (2013)
Oku M, Ichiki Y, Shiraishi A, Takahara T, Maeda T, Sakai Y.
Hyper-activation of the target of rapamycin (Tor) kinase 1 decreases Intracellular
glutathione content in Saccharomyces cerevisiae as
revealed by LC-MS/MS analysis.
Biosci Biotechnol Biochem. 77: 1608-1611 (2013)
Goranov AI, Gulati A, Dephoure N, Takahara T, Maeda T, Gygi SP, Manalis S, Amon A.
Changes in cell morphology are coordinated with cell growth through the TORC1 pathway.
Curr Biol. 23: 1269-1279 (2013)
Takahara T, Maeda T.
Transient sequestration of TORC1 into stress granules during heat stress.
Mol. Cell. 47: 242-52 (2012) [Previews] [新着論文レビュー]
Takahara T, Maeda T.
TORC1 of fission yeast is rapamycin-sensitive.
Genes to Cells. 17: 698-708 (2012)
Tanigawa M, Kihara A, Terashima M, Takahara T, Maeda T.
Sphingolipids regulate the yeast high-osmolarity glycerol response pathway.
Mol. Cell. Biol. 32: 2861-70 (2012) [Selected in Spotlights]
Maeda T.
The signaling mechanism of ambient pH sensing and adaptation in yeast and
fungi. (review)
FEBS Journal. 279: 1407-1413 (2012)
Hatakeyama R, Kamiya M, Takahara, T, Maeda
T.
Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin
ligase via the arrestin-like protein Aly2.
Mol. Cell. Biol. 30: 5598-5607 (2010)
Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S,
Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier
H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi
H.
Dynamic distribution of muscle-specific calpain in mice has a key role
in physical-stress adaptation and is impaired in muscular
dystrophy.
J. Clin. Invest. 120: 2672-2683 (2010)
Nishizawa M,
Tanigawa M, Hayashi M, Maeda T, Yazaki Y, Saeki Y, Toh-e A.
Pho85 kinase, a cyclin-dependent kinase, regulates nuclear accumulation
of the Rim101 transcription factor in the stress-response of Saccharomyces
cerevisiae.
Eukaryotic Cell. 9: 943-951 (2010)
Ohne Y, Takahara T, Maeda T.
Evaluation of mTOR function by a gain-of-function approach.(review)
Cell Cycle. 8:4:573-579(2009)
Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, Maeda T.
Isolation of hyperactive mutants of mammalian target of rapamycin.
J. Biol. Chem. 283: 31861-31870 (2008)
Yorikawa C, Takaya E, Osako Y, Tanaka R, Terasawa Y, Hamakubo T, Mochizuki
Y, Iwanari H, Kodama T, Maeda T, Hitomi K, Shibata H, Maki M.
Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins
in its N-terminal region and partly localizes to endocytic membrane compartments.
J. Biochem. 143: 731-745 (2008)
Takahara T, Hara K, Yonezawa K, Sorimachi H,
Maeda T.
Nutrient-dependent multimerization of the mammalian target of
rapamycin through the N-terminal HEAT repeat region.
J. Biol. Chem. 281: 28605-14 (2006)
Ono Y, Torii F, Ojima K, Doi N, Yoshioka K,
Kawabata Y, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H.
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in
a genetic reporter system.
J. Biol. Chem. 281: 18519-18531 (2006)
Hayashi M and Maeda T.
Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae.
J. Biochem. 139: 797-803 (2006)
Nakajima M, Shimada A, Takashi Y, Kim Y-C, Park S-H, Ueguchi-Tanaka M, Suzuki H, Kato E, Iuchi S, Kobayashi M, Maeda T, Matsuoka M,
Yamaguchi I
Identification and characterization of Arabidopsis gibberellin receptors.
Plant J. 46: 880-889 (2006)
Hata
S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K,
Sorimachi H.
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes
the beta-subunit of coatomer complex, beta-COP.
J. Biol. Chem. 281: 11214-11224 (2006)
Hayashi M, Fukuzawa T,
Sorimachi H, Maeda T.
Constitutive activation of the pH-responsive Rim101
pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway.
Mol. Cell. Biol. 21: 9478-9490 (2005)
Furukawa K, Hoshi Y, Maeda T, Nakajima T, Abe K.
Aspergillus nidulans HOG pathway is activated only by two-component signalling
pathway in response to osmotic stress.
Mol. Microbiol. 56: 1246-1261 (2005)
Ohkouchi
S, Saito H, Aruga F, Maeda T, Shibata H, Maki M.
Dictyostelium discoideum requires an Alix/AIP1 homolog, DdAlix, for morphogenesis
in alkaline environments.
FEBS Lett. 579: 1745-1750 (2005)
Ozawa
H, Ashizawa S, Naito M, Yanagihara M, Ohnishi N, Maeda T, Matsuda Y, Jo Y,
Higashi H, Kakita A, Hatakeyama M.
Paired-like
homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits
cyclin degradation.
Oncogene. 23: 6590-6602 (2004)
Sato N, Kawahara
H, Toh-e A, Maeda T.
Phoshorelay-regulated degradation of the yeast Ssk1p
response regulator by the ubiquitin-proteasome system.
Mol. Cell. Biol. 23: 6662-6671 (2003)
Takahashi N, Sasagawa N, Usuki F, Kino Y,
Kawahara H, Sorimachi H, Maeda T, Suzuki K, Ishiura S.
Coexpression of the CUG-binding
protein reduces DM protein kinase expression in COS cells.
J. Biochem. 130: 581-587 (2001)
Umeda T, Kouchi Z, Kawahara H, Tomioka S,
Sasagawa N, Maeda T, Sorimachi H, Ishiura S, Suzuki K.
Limited proteolysis of filamin
is catalyzed by caspase-3 in U937 and Jurkat cells.
J. Biochem. 130: 535-542 (2001)
Hata S, Nishi K, Kawamoto T, Lee HJ,
Kawahara H, Maeda T, Shintani Y, Sorimachi H, Suzuki K.
Both the conserved and
the unique gene structure of stomach-specific calpains
reveal processes of calpain gene evolution.
J. Mol. Evol. 53: 191-203 (2001)
Yao R, Maeda T, Takada S, Noda T.
Identification of a PDZ domain containing
Golgi protein, GOPC, as an interaction partner of frizzled.
Biochem. Biophys. Res. Commun. 286: 771-778 (2001)
Hata S, Sorimachi H, Nakagawa K, Maeda T,
Abe K, Suzuki K.
Domain II of m-calpain is a Ca2+-dependent cysteine protease.
FEBS Lett. 501: 111-114 (2001)
Futai E, Kubo T,
Sorimachi H, Suzuki K, Maeda T.
Molecular cloning of PalBH, a mammalian
homologue of the Aspergillus atypical calpain PalB.
Biochem. Biophys. Acta. 1517: 316-319 (2001)
Koike H, Kouchi Z, Kinouchi T, Maeda T,
Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S.
Metabolism of amyloid precursor protein in COS cells transfected with a
beta-secretase candidate.
Cytotechnology. 33: 213-219 (2000)
Ohtoshi A,
Maeda T, Higashi H, Ashizawa S, Hatakeyama M.
Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by
the cyclin A-Cdk2 complex.
Biochem. Biophys. Res. Commun. 268 :530-534 (2000)
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M,
Hatakeyama M.
β3-endonexin as a novel inhibitor of cyclin A-associated
kinase.
Biochem. Biophys. Res. Commun. 267: 947-952 (2000)
Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama
M.
Physical interaction and functional antagonism between the RNA polymerase
II elongation factor ELL and p53.
J. Biol. Chem. 274: 17003-17010 (1999)
Takehana K, Sato
S, Kobayashi T, Maeda T.
A radicicol-related macrocyclic nonaketide compound,
antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific
manner.
Biochem. Biophys. Res. Commun. 257: 19-23 (1999)
Futai E, Maeda T, Sorimachi H, Kitamoto K, Ishiura S, Suzuki K.
The
protease activity of a calpain-like cysteine protease in Saccharomyces
cerevisiae is required for alkaline adaptation and
sporulation.
Mol. Gen. Gent. 260: 559-568 (1999)
Noto S, Maeda T,
Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M.
A novel human RasGAP-like gene that maps within the prostate cancer susceptibility
locus at chromosome 1q25.
FEBS Lett. 441:127-131 (1998)
Iwabe K, Teramura M,
Yoshinaga K, Kobayashi S, Hoshikawa Y, Maeda T, Hatakeyama M, Mizoguchi
H.
K-252a-induced polyploidization and differentiation of a human megakaryocytic
cell line, Meg-J: transient elevation and subsequentsuppression of cyclin
B1 and cdc2 expression in the process of polyploidization.
Br. J. Haematol. 102: 812-819 (1998)
Takekawa M, Maeda T, Saito H.
Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK
MAPK pathways.
EMBO J. 17: 4744-4752 (1998)
2) 総説等
Takahara T, Maeda T.
Evolutionarily conserved regulation of TOR signalling.
J. Biochem. 154: 1-10 (2013)
高原照直、前田達哉
ストレス刺激に応答したTOR複合体1（TORC1）の活性制御機構
生化学 85: 205-213 (2013)
特集「ターゲット・オブ・mTOR−明らかになるmTORの標的分子と生理機能」監修
細胞工学 31(12) (2012)
Takahara T, Maeda T.
Stress granules: The last refuge of TORC1?
Cell Cycle 11: 3707-3708 (2012)
高原照直、前田達哉
熱ストレスのもとでのTOR複合体1のストレス顆粒への局在化
新着論文レビュー
高原照直、前田達哉
mTORシグナル
シグナル伝達キーワード事典
山本雅、仙波憲太郎、山梨裕司編 （株）羊土社 (2012)
前田達哉
mTORシグナルの分子メカニズムと生理的役割
Jpn. J. Antibiotics 65 Suppl. A: 101-105 (2012)
高原照直, 前田達哉
mTOR阻害薬
腎と透析 67:5:607-613(2009)
前田達哉
浸透圧応答経路
酵母のすべて −系統、細胞から分子まで−
大隅良典、下田親編 299-304 シュプリンガー・ジャパン（株） (2007)
佐藤直人、前田達哉
タンパク質分解を介した真核生物His-Aspリン酸基リレーの制御機構
生化学 76: 1576-1578 (2004)
前田達哉
酵母ツーハイブリッド法とその応用技術
ポストシークエンス タンパク質実験法（３）構造・機能解析の基礎
東京化学同人 (2002)
前田達哉
酵母の浸透圧応答
蛋白質 核酸 酵素 44: 2206-2213 (1999)
前田達哉、畠山昌則
RB癌抑制遺伝子と細胞周期
血液・腫瘍科 34: 271-277 (1997)
渡辺康行、前田達哉
MAPキナーゼを調整するチロシンホスファターゼ
実験医学 14: 631-635 (1996)
前田達哉
真核生物のtwo-component system
実験医学 13: 344-346 (1995)
前田達哉
PTPaseとシグナル伝達
細胞工学 12: 623-630 (1993)
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