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39ACHIEVEMENTPUBLICATIONHiramoto T., Tahara M., Liao J., Soda Y., Miura Y., Kurita R., Hamana H., Inoue K., Kohara H., Hijikata Y., Okano S., Yamaguchi Y., Oda Y., Ichiyanagi K., Toh H., Sasaki H., Kishi H., Ryo A., Muraguchi A,. Takeda M., Tani K. Non-transmissi-ble measles virus vector with segmented RNA genome establishes different types of iPSCs from hematopoietic cells. Mol Ther 28:129-141, 2020. DOI: 10.1016/j.ymthe.2019.09.007Tahara M., Takishima Y., Miyamoto S., Nakatsu Y., Someya K., Sato M., Tani K., Takeda M. Photocontrollable mononega-viruses. Proc Natl Acad Sci U S A. 116:11587-11589,2019. DOI: 10.1073/pnas.1906531116Jia Y., Miyamoto S., Soda Y., Takishima Y., Sagara M., Liao J., Hirose-Yotsuya L., Hijikata Y., Miura Y., Hara K., Iwanaga A., Ota Y., Tani K. Extremely low organ toxicity and strong antitumor activity of miR-34-regulated oncolytic coxsackievirus B3.　Mol Ther Oncolytics. 12: 246-258. 2019. DOI: 10.1016/j.omto.2019.01.003TANI KENZABUROJSPS JUNIOR SCIENTIST, CLINICAL AND RESEARCH ASSOCIATE AND LECTURER (1986) THE UNIVERSITY OF TOKYOASSOCIATE PROFESSOR (1995) THE UNIVERSITY OF TOKYOPROFESSOR (2002) KYUSHU UNIVERSITYDIRECTOR (2010) KYUSHU UNIVERSITYPROJECT PROFESSOR (2015)THE UNIVERSITY OF TOKYOPROJECT PROFESSOR (2020)IQB / INSTITUTE FOR QUANTITATIVE BIOSCIENCES, THE UNIVERSITY OF TOKYO●MEMBER■ PROJECT PROFESSOR :TANI KENZABURO■ PROJECT ASSOCIATE PROFESSOR :SODA YASUSHI■ SENIOR ASSISTANT PROFESSOR : MIYAMOTO SHOHEI■ PROJECT RESEARCHER : LIAO JIYUAN■ PROJECT ACADEMIC SUPPORT STAFF : SAKAMOTO AKIRA■ PROJECT ACADEMIC SUPPORT STAFF : ITO SHUN■ PROJECT ACADEMIC SUPPORT STAFF : OHNO HARUKA■ PROJECT ACADEMIC SUPPORT STAFF : USHIJIMA MICHIKOPUBLICATIONPUBLICATIONesearch Purpose：5-aminolevulinic acid（5-ALA), one of the natural amino acids, exists in the mito-chondria of cells and produces energy “ATP” in all living organisms. We have been developing new diagnostic and therapeutic modalities against intractable disease including malignancies using 5-ALA and will contribute the medical progress. Our Current Research：5-ALA is the firstproduct in porphyrin synthetic pathway and it produces heme in mitochondria and supplies heme proteins to cells. Various heme proteins are known and play various physiological roles including mitochondria activation, anti-inflammation, antioxidation and anti-infection. Making full use of 5-ALA, our team which has long been involved in the developing new cell and gene therapy modali-ties has been currently developing new diagnostic and therapeutic methods for sickle cell disease and malignancies. R(1) Metabolic Pathway of 5-ALA (2) Sickle Cell Disease (SCD)