IQB Handbook

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37ACHIEVEMENTPUBLICATIONTsuneizumi K, Nakayama T, Kamoshida Y, Kornberg TB, Christian JL, Tabata T. Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature. 1997 Oct 9;389(6651):627-31. DOI:10.1038/39362Tanimoto H, Itoh S, ten Dijke P, Tabata T. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol Cell. 2000 Jan;5(1):59-71. DOI:10.1016/s1097-2765(00)80403-7Yamazaki D, Hiroi M, Abe T, Shimizu K, Minami-Ohtsubo M, Maeyama Y, Horiuchi J, Tabata T. Two Parallel Pathways Assign Opposing Odor Valences during Drosophila Memory Formation. Cell Rep. 2018 Feb 27;22(9):2346-2358. DOI:10.1016/j.celrep.2018.02.012(1) Kenyon cells of mushroom bodies and their output neurons play a central role in the olfactory memory formation. (2) The performance of olfactory memory is measured with a T-maze apparatus. (3) Neuronal activity is recorded under a two-photon microscope. (4) Electrophysiological recording of neuronal activity.TABATATETSUYAPH.D. (1986) HOKKAIDO UNIVERSITYRESEARCH ASSOCIATE (1986) HOKKAIDO UNIVERSITYRESEARCH ASSOCIATE (1989) KYOTO UNIVERSITYPOSTDOCTRAL FELLOW (1990) UNIVERSITY OF CALIFORNIA, SAN FRANCISCOASSOCIATE PROFESSOR (1994) INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES, THE UNIVERSITY OF TOKYOPROFESSOR (2000) INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES, THE UNIVERSITY OF TOKYOPROFESSOR (2018) IQB / INSTITUTE FOR QUANTITATIVE BIOSCIENCES, THE UNIVERSITY OF TOKYO●MEMBER■ PROFESSOR :TABATA TETSUYA■ LECTURER :YAMAZAKI DAISUKE■ RESEARCH ASSOCIATE : ABE TAKASHI■ TECHNICAL SPECIALIST : MAEYAMA YUKO■ PROJECT ACADEMIC SUPPORT STAFF :TAKISHITA HITOMI■ PROJECT ACADEMIC SUPPORT STAFF :SATO MISAKOPUBLICATIONPUBLICATIONost of our knowledge of the world and most of our skills are not innate but learned. Thus, we are who we are in large part because of what we have learned and what we remem-ber and forget.” Eric Kandel et al., 2014, Cell.Drosophila can form an association between a particular odor and an electric shock, acquir-ing a conditional avoidance response to the odor. This is a simple form of memory termed aversive memory. Similarly, Drosoph-ila can form a memory by associating an odor with the taste of sugar in a process called appetitive memory. The research in my laboratory focuses primarily on the question of how and where a memory is formed, stored and retrieved in the Drosophila brain. The study of Drosophila olfactory learning offers the advantages of simple neural circuits and advanced molecular genetics, allowing us to identify the synapses that provide plasticity and transduce critical signals. We are currently focusing on the neuropile called the mushroom body, which is thought to function as a coincidence detector during olfactory learning. The mushroom body consists of many types of neurons. Each plays a role in a different step of memory forma-tion—for example, acquisition, consolidation and retrieval—and in a different context indicating that memory formation can be divided into several stages and that each of these stages is performed by a distinct unit. Our projects include identification of the cellular and molecular mechanisms underly-ing these processes. To this end, we utilize various strategies and techniques, such as behavior assay, optogenetics and functional imaging.“M