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13ACHIEVEMENTPUBLICATIONNakamura T., Arima-Yoshida F., Sakaue F., Nasu-Nishimura Y., Takeda Y., Matsuura K., Akshoomoff N., Mattson S.N., Grossfeld P.D., Manabe T. Akiyama T. PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016 Mar 16;7:10861. DOI: 10.1038/ncomms10861Taniue K., Kurimoto A., Sugimasa H., Nasu E., Takeda Y., Iwasaki K., Nagashima T., Okada-Hatakeyama M., Oyama M., Kozuka-Hata H., Hiyoshi M., Kitayama J., Negishi L., Kawasaki Y., Akiyama T. Long non-coding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A. 2016 Feb 2; 113(5): 1273–1278. DOI: 10.1073/pnas.1500992113Yamazumi Y., Sasaki O., Imamura M., Oda T., Ohno Y., Shiozaki-Sato Y., Nagai S., Suyama S., Kamoshida Y., Funato K., Yasui T., Kikutani H., Yamamoto K., Dohi M., Koyasu S., Akiyama T. The RNA-binding protein Mex-3B is required for IL-33 induction in the development of allergic airway inflammation. Cell Rep. 2016 Aug 30;16(9):2456-71. DOI: 10.1016/j.celrep.2016.07.062AKIYAMATETSUPH.D. (1981) UNIVERSITY OF TOKYOASSOCIATE PROFESSOR (1986) KYOTO UNIVERSITYASSOCIATE PROFESSOR (1989) THE UNIVERSITY OF TOKYOASSOCIATE PROFESSOR (1990)OSAKA UNIVERSITYPROFESSOR (1994)OSAKA UNIVERSITYPROFESSOR (1998)INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES, THE UNIVERSITY OF TOKYODIRECTOR (2009-2017)INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES, THE UNIVERSITY OF TOKYOPROJECT PROFESSOR (2018)IQB / INSTITUTE FOR QUANTITATIVE BIOSCIENCES, THE UNIVERSITY OF TOKYO●MEMBER■ PROJECT PROFESSOR :AKIYAMA TETSU■ VISITING ASSOCIATE PROFESSOR : KAWASAKI YOSHIHIRO■ VISITING ASSOCIATE PROFESSOR : NAKAMURA TSUTOMU■ PROJECT RESEARCHASSOCIATE :HAYASHI TOMOATSU■ PROJECT RESEARCHASSOCIATE :YAMAZUMI YUSUKE■ PROJECT RESEARCHER : KAMOSHIDA YUKI■ PROJECT ACADEMIC SUPPORT SPECIALIST : SHIMIZU NAOMI■ PROJECT ACADEMIC SUPPORT SPECIALIST : CONA BRANDON JAMES■ PROJECT ACADEMIC SUPPORT STAFF : YAMADA AI■ TECHNICAL ASSISTANT : IIDA MAIPUBLICATIONPUBLICATIONur research is concentrated in the following areas:1. Tumor heterogeneityRecent studies suggest that a subpopulation within the tumor mass, called cancer stem cells, has high tumorigenic potential. Therefore, cancer stem cells could be critical targets for cancer chemotherapy. We are focusing our investigation on the elucidation of the molecular mechanisms of cancer stem cell self-renewal and differentia-tion. We are also analyzing the interaction of cancer stem cells with immune cells and cancer-associated fibroblasts. 2. Analysis of long-lived mutant miceMice deficient for Mex-3B live longer than wild-type mice. We are investigating the role of Mex-3B in aging and senescence.3. Autism and socio-emotional learning The onset of autism is thought to be closely tied to the dysfunction of the amygdala, but the molecular mechanisms linking the impaired function of this region to autistic behavior are not well-understood. We are exploring the functions of the autism-related protein PX-RICS in emotional learning in the amygdala.O(1) Single cell analysis of tumor heterogeneity (2) Glioblastoma stem cells lose their tumorigenic capacity under serum-containing culture conditions.