Pressrelease

2021-12-03 / Last updated : 2021-12-03 adiqb1 Laboratory of Stem Cell Therapy

Drug screening model of therapeutic agents for liver fibrosis using hiPSC-derived quiescent hepatic stellate cells

Yuta Koui
Atsushi Miyajima
Taketomo Kido
Stem Cell Reports
  • Development of a novel drug screening model for liver fibrosis using hiPSC-derived quiescent hepatic stellate cells.
  • ACTA2-RFP reporter iPSC line is a useful tool for quantitatively monitoring the activation process of hepatic stellate cells.
  • Identification of therapeutic agents for liver fibrosis using a novel drug screening system.

 

Pressrelease
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Journals

Journal: Stem Cell Reports

Title: Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling

Author: Yuta Koui, Misao Himeno, Yusuke Mori, Yasuhiro Nakano, Eiko Saijou, Naoki Tanimizu,　Yoshiko Kamiya, Hiroko Anzai, Natsuki Maeda, Luyao Wang, Tadanori　Yamada, Yasuyuki Sakai, Ryuichiro Nakato, Atsushi Miyajima, Taketomo Kido

DOI: 10.1016/j.stemcr.2021.11.002

URL：https://doi.org/10.1016/j.stemcr.2021.11.002

Contact

Taketomo Kido

Project Lecturer, Institute for Quantitative Biosciences