Inflammation and tumorigenesis.
Our research is concentrated in the following areas
Asthma is a chronic inflammatory disorder of the airways. Most asthma
patients have mild-to-moderate disease that can be effectively treated
with steroids. However, approximately 10% of asthma patients respond
poorly to steroids. These severe asthma patients account for 40% of
the total cost for asthma care and 30%～50% of asthma morbidity. We
are analyzing the role of the RNA-binding protein Mex-3B in steroidresistant
allergic airway inflammation.
２．Long non-coding RNA and cancer development
Long non-coding RNAs (lncRNAs) are aberrantly expressed in
many disease conditions, including cancer. Accumulating evidence
indicates that some lncRNAs may play critical roles in cancer
progression and metastasis. We are investigating the role of lncRNAs in